Design, Synthesis and Antimicrobial Activity of α-Aminophosphonates of Quinoline and their Molecular Docking Studies Against DNA Gyrase A

Title:Design, Synthesis and Antimicrobial Activity of α-Aminophosphonates of Quinoline and their Molecular Docking Studies Against DNA Gyrase A

Volume: 10 Issue: 10

Author(s): Doddaga Srinivasulu, Muttana Vijaya Bhaskara Reddy, Donka Rajasekhar, Meriga Balaji and Chamarthi Nagaraju

Affiliation:

Keywords: α-Aminophosphonates, Antibacterial activity, Antifungal activity, CeCl3.7H2O, Molecular docking.

Abstract: A new series of diethyl (substituted phenyl/thiophen-2-yl)(quinolin-8-ylamino)methylphosphonates 4a-j of biological interest was synthesized by Kabachnik-Fields reaction. The title compounds were screened for their antimicrobial activity. Some of the compounds in the series exhibited promising antibacterial and antifungal activity. The newly synthesized compounds were subjected to molecular docking studies for the inhibition of the enzyme DNA Gyrase A, which is a new target for microbes (E. coli). The docking studies shown that 4b, 4c, 4e, 4g and 4h posses the highest binding energies compared to ciprofloxacin.

Cite this article as:

Srinivasulu Doddaga, Vijaya Bhaskara Reddy Muttana, Rajasekhar Donka, Balaji Meriga and Nagaraju Chamarthi, Design, Synthesis and Antimicrobial Activity of α-Aminophosphonates of Quinoline and their Molecular Docking Studies Against DNA Gyrase A, Letters in Drug Design & Discovery 2013; 10 (10) . https://dx.doi.org/10.2174/15701808113109990035

DOI https://dx.doi.org/10.2174/15701808113109990035	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X