Capillary Zone Electrophoresis for Separation and Quantitative Determination of Mexiletine and its Main Phase I Metabolites

Title:Capillary Zone Electrophoresis for Separation and Quantitative Determination of Mexiletine and its Main Phase I Metabolites

Volume: 7 Issue: 1

Author(s): Claudio Bruno, Maria Maddalena Cavalluzzi, Alessia Carocci, Alessia Catalano, Carlo Franchini and Giovanni Lentini

Affiliation:

Keywords: Anti-arrhythmics, capillary zone electrophoresis, metabolites, mexiletine.

Abstract: The simultaneous separation and quantification of the analytes within the minimum analysis time and the maximum resolution and efficiency are the main objectives in the development of a capillary electrophoretic method for the determination of solutes. In this paper we describe a specific, sensitive and robust method, using capillary zone electrophoresis with internal standard and UV detection, for the separation and quantification of the anti-arrhythmic drug mexiletine, its main phase I metabolites, and its main nitrogenous degradation product.

Cite this article as:

Bruno Claudio, Cavalluzzi Maddalena Maria, Carocci Alessia, Catalano Alessia, Franchini Carlo and Lentini Giovanni, Capillary Zone Electrophoresis for Separation and Quantitative Determination of Mexiletine and its Main Phase I Metabolites, Drug Metabolism Letters 2013; 7 (1) . https://dx.doi.org/10.2174/18723128112069990011