Abstract
Metabolism in cancer cells is reprogrammed. Cancer cells largely depend on glycolysis for ATP production. The metabolic alterations in cancer cells facilitate resistance to cell death as well as biosynthesis of nucleotides and lipids, building blocks for growth. The reprogrammed metabolism is increasingly seen as a target in cancer therapy. This review describes the metabolic reprogramming of cancer cells and illustrates how this is related to cell cycle and apoptosis resistance. Is also describes various scenarios for targeting cancer cell metabolism and highlights options for interventions with nutrition and bioactive food components.
Keywords: Mitochondria, metabolic reprogramming, energy metabolism, targeting metabolism, AMPK, mTOR, polyphenols, apoptosis, ROS, bioactive food components.
Current Pharmaceutical Design
Title:Reprogrammed Metabolism of Cancer Cells as a Potential Therapeutic Target
Volume: 20 Issue: 15
Author(s): Jaap Keijer and Dorien A.M. van Dartel
Affiliation:
Keywords: Mitochondria, metabolic reprogramming, energy metabolism, targeting metabolism, AMPK, mTOR, polyphenols, apoptosis, ROS, bioactive food components.
Abstract: Metabolism in cancer cells is reprogrammed. Cancer cells largely depend on glycolysis for ATP production. The metabolic alterations in cancer cells facilitate resistance to cell death as well as biosynthesis of nucleotides and lipids, building blocks for growth. The reprogrammed metabolism is increasingly seen as a target in cancer therapy. This review describes the metabolic reprogramming of cancer cells and illustrates how this is related to cell cycle and apoptosis resistance. Is also describes various scenarios for targeting cancer cell metabolism and highlights options for interventions with nutrition and bioactive food components.
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Cite this article as:
Keijer Jaap and van Dartel A.M. Dorien, Reprogrammed Metabolism of Cancer Cells as a Potential Therapeutic Target, Current Pharmaceutical Design 2014; 20 (15) . https://dx.doi.org/10.2174/13816128113199990483
DOI https://dx.doi.org/10.2174/13816128113199990483 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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