Solvent-Free Synthesis of Functionalized Thiazoles Using Multicomponent Reaction of Isothiocyanates

Title:Solvent-Free Synthesis of Functionalized Thiazoles Using Multicomponent Reaction of Isothiocyanates

Volume: 16 Issue: 9

Author(s): Seyyedeh Zahra Sayyed-Alangi, Zinatossadat Hossaini, Faramarz Rostami-Charati and Hadi Sajjadi-Ghotabadi

Affiliation:

Keywords: Arylisothiocyanates, one-pot reactions, tetramethylguanidine, thiazoles.

Abstract: An efficient synthesis of thiazoles is described via an one-pot reaction between acid chlorides, ammonium thiocyanate tetramethylguanidine and α-bromocarbonyl compounds under solvent-free conditions without using any catalyst. The method offers several advantages including high yields of products and an easy work-up procedure at room temperature in excellent yield.

Cite this article as:

Sayyed-Alangi Zahra Seyyedeh, Hossaini Zinatossadat, Rostami-Charati Faramarz and Sajjadi-Ghotabadi Hadi, Solvent-Free Synthesis of Functionalized Thiazoles Using Multicomponent Reaction of Isothiocyanates, Combinatorial Chemistry & High Throughput Screening 2013; 16 (9) . https://dx.doi.org/10.2174/13862073113169990036