Abstract
A variety of chiral bisamide ligands have been prepared and widely used in asymmetric catalytic syntheses with highly regioand enantioselective products, especially in the transition-metal-catalyzed asymmetric allylic alkylation reactions. The achievements in the asymmetric allylic alkylation reactions with various nucleophiles have been reviewed. The applications of some typical chiral bisamides in decarboxylative asymmetric allylic alkylation of enol carbonates, [3+2] cycloaddition of vinyl cyclopropanes and alkylidene azlactones, and aldol reactions are also introduced.
Keywords: Bisamide, ligand, asymmetric catalysis, allylic alkylation, nucleophile.
Current Organic Synthesis
Title:Application of Chiral Bisamide Ligands in Asymmetric Catalytic Syntheses
Volume: 10 Issue: 3
Author(s): Chan Zhou and Jiaxi Xu
Affiliation:
Keywords: Bisamide, ligand, asymmetric catalysis, allylic alkylation, nucleophile.
Abstract: A variety of chiral bisamide ligands have been prepared and widely used in asymmetric catalytic syntheses with highly regioand enantioselective products, especially in the transition-metal-catalyzed asymmetric allylic alkylation reactions. The achievements in the asymmetric allylic alkylation reactions with various nucleophiles have been reviewed. The applications of some typical chiral bisamides in decarboxylative asymmetric allylic alkylation of enol carbonates, [3+2] cycloaddition of vinyl cyclopropanes and alkylidene azlactones, and aldol reactions are also introduced.
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Cite this article as:
Zhou Chan and Xu Jiaxi, Application of Chiral Bisamide Ligands in Asymmetric Catalytic Syntheses, Current Organic Synthesis 2013; 10 (3) . https://dx.doi.org/10.2174/1570179411310030005
DOI https://dx.doi.org/10.2174/1570179411310030005 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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