Antimicrobial Treatment to Impair Expansion of Abdominal Aortic Aneurysm (AAA): A Systematic Review of the Clinical Evidence

Title:Antimicrobial Treatment to Impair Expansion of Abdominal Aortic Aneurysm (AAA): A Systematic Review of the Clinical Evidence

Volume: 11 Issue: 3

Author(s): David Bergqvist, Johannes H.N. Lindeman, Jes S. Lindholt and Martin Bjorck

Affiliation:

Keywords: Aortic aneurysm, expansion, macrolide, tetracycline, antibiotic.

Abstract: Antimicrobial treatment to attenuate expansion of abdominal aortic aneurysm has been suggested, especially with the focus on Chlamydophila. In this systematic literature review only four randomized trials were identified. In two small studies there is an indication of an effect of roxithromycin. In conclusion, however, more studies are needed, and they must be properly sized based on power calculations as well as antimicrobially relevant. Such trials are on the way both in Europe and the US, the results being awaited with interest.

Cite this article as:

Bergqvist David, Lindeman Johannes H.N., Lindholt Jes S. and Bjorck Martin, Antimicrobial Treatment to Impair Expansion of Abdominal Aortic Aneurysm (AAA): A Systematic Review of the Clinical Evidence, Current Vascular Pharmacology 2013; 11 (3) . https://dx.doi.org/10.2174/1570161111311030002