Abstract
Antimicrobial treatment to attenuate expansion of abdominal aortic aneurysm has been suggested, especially with the focus on Chlamydophila. In this systematic literature review only four randomized trials were identified. In two small studies there is an indication of an effect of roxithromycin. In conclusion, however, more studies are needed, and they must be properly sized based on power calculations as well as antimicrobially relevant. Such trials are on the way both in Europe and the US, the results being awaited with interest.
Keywords: Aortic aneurysm, expansion, macrolide, tetracycline, antibiotic.
Current Vascular Pharmacology
Title:Antimicrobial Treatment to Impair Expansion of Abdominal Aortic Aneurysm (AAA): A Systematic Review of the Clinical Evidence
Volume: 11 Issue: 3
Author(s): David Bergqvist, Johannes H.N. Lindeman, Jes S. Lindholt and Martin Bjorck
Affiliation:
Keywords: Aortic aneurysm, expansion, macrolide, tetracycline, antibiotic.
Abstract: Antimicrobial treatment to attenuate expansion of abdominal aortic aneurysm has been suggested, especially with the focus on Chlamydophila. In this systematic literature review only four randomized trials were identified. In two small studies there is an indication of an effect of roxithromycin. In conclusion, however, more studies are needed, and they must be properly sized based on power calculations as well as antimicrobially relevant. Such trials are on the way both in Europe and the US, the results being awaited with interest.
Export Options
About this article
Cite this article as:
Bergqvist David, Lindeman Johannes H.N., Lindholt Jes S. and Bjorck Martin, Antimicrobial Treatment to Impair Expansion of Abdominal Aortic Aneurysm (AAA): A Systematic Review of the Clinical Evidence, Current Vascular Pharmacology 2013; 11 (3) . https://dx.doi.org/10.2174/1570161111311030002
DOI https://dx.doi.org/10.2174/1570161111311030002 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
Call for Papers in Thematic Issues
TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Chemokines in Cardiovascular Remodeling: Clinical and Therapeutic Implications
Current Molecular Medicine Complex Atheromatosis of the Aortic Arch in Cerebral Infarction
Current Cardiology Reviews Circadian Variation of Cardiovascular Events and Morning Blood Pressure Surge
Vascular Disease Prevention (Discontinued) Levosimendan Preoperative
Current Pharmaceutical Design Phyto-derived Products as Matrix Metalloproteinases Inhibitors in Cardiovascular Diseases
Current Hypertension Reviews The Tree of Sirtuins and the Garden of Cardiovascular Youth
Current Vascular Pharmacology The Appearance of Middle Meningeal Artery Fistulae After Willis Covered Stent for Traumatic Carotid-cavernous Fistulae: Two Case Reports
Current Medical Imaging Imaging of Abdominal Aortic Aneurysm: The Present and the Future
Current Vascular Pharmacology New Strategies in Drug Development Focusing on the Anti-Protease- Protease Balance in Alpha-1 Antitrypsin Deficiency
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Takotsubo Cardiomyopathy
Current Pharmaceutical Design Neurocysticercosis: The Enigmatic Disease
Central Nervous System Agents in Medicinal Chemistry The Simulation and Experimental Comparison of Parameter Factors Impact on MRI Artifact
Current Medical Imaging Atherogenesis in Renal Patients: A Model of Vascular Disease?
Current Vascular Pharmacology Parasite Polyamines as Pharmaceutical Targets
Current Pharmaceutical Design Nitrone Derivatives as Therapeutics: From Chemical Modification to Specific-targeting
Current Topics in Medicinal Chemistry Magnetic Resonance Angiography and Multidetector CT Angiography in the Diagnosis of Takayasu's Arteritis: Assessment of Disease Extent and Correlation with Disease Activity
Current Medical Imaging Cholinergic Treatment of Traumatic Brain Injury
Current Drug Therapy Mast Cells: Pivotal Players in Cardiovascular Diseases
Current Cardiology Reviews Role of Diagnostic Ultrasound in Patient Selection for Stroke Intervention
Recent Patents on CNS Drug Discovery (Discontinued) Patent Selections
Recent Patents on DNA & Gene Sequences