Strategies to Direct Angiogenesis within Scaffolds for Bone Tissue Engineering

Title:Strategies to Direct Angiogenesis within Scaffolds for Bone Tissue Engineering

Volume: 19 Issue: 19

Author(s): Greg M. Harris, Katy Rutledge, Qingsu Cheng, James Blanchette and Ehsan Jabbarzadeh

Affiliation:

Keywords: Angiogenesis, tissue engineering, bone, scaffold, microscale patterning, growth factor delivery, cell transplantation.

Abstract: There is a profound need for orthopaedic grafting strategies due to various trauma and musculoskeletal diseases. Tissue engineering offers a promising avenue to develop viable grafts for bone repair. The transfer of bone tissue engineering strategies to clinical applications is limited by the failure to adequately vascularize scaffolds after implantation. This review focuses on the natural processes for bone and vessel formation as well as the microenvironmental cues and microscale fabrication techniques to properly coordinate these events towards successful vascularization of tissue engineered scaffolds.

Cite this article as:

Harris Greg M., Rutledge Katy, Cheng Qingsu, Blanchette James and Jabbarzadeh Ehsan, Strategies to Direct Angiogenesis within Scaffolds for Bone Tissue Engineering, Current Pharmaceutical Design 2013; 19 (19) . https://dx.doi.org/10.2174/1381612811319190011