Abstract
In an attempt to develop effective antimicrobial therapeutics, a new series of pyrazoles incorporating 1,3,5- oxadiazole and 1,2,4-triazole moieties and their S-glycosides has been synthesized. All the newly synthesized compounds were confirmed by IR, 1H, 13C NMR and mass spectral studies. The newly synthesized compounds were tested for their antimicrobial activity against two fungal species and two bacterial species. The obtained data indicated that some of the tested compounds exhibited both antibacterial and antifungal activities, particularly compounds 14, 16, 17 and 18 showed a comparable effect to a well known antibacterial and antifungal agent.
Keywords: Oxadiazoles, Pyrazoles, Triazoles, Thioglycosides, Antimicrobial Activities
Letters in Drug Design & Discovery
Title:Design, Synthesis, Crystal Structure, and Antimicrobial Evaluation of Novel Pyrazolyl-1,3,5-oxadiazoles, Pyrazolyl-1,2,4-triazoles and their Related Thioglycosides
Volume: 10 Issue: 5
Author(s): Nora M. A. El-Ebiary, Emad M. El-Telbani, Randa H. Swellem, Ibrahim F. Zeid and Galal A. M. Nawwar
Affiliation:
Keywords: Oxadiazoles, Pyrazoles, Triazoles, Thioglycosides, Antimicrobial Activities
Abstract: In an attempt to develop effective antimicrobial therapeutics, a new series of pyrazoles incorporating 1,3,5- oxadiazole and 1,2,4-triazole moieties and their S-glycosides has been synthesized. All the newly synthesized compounds were confirmed by IR, 1H, 13C NMR and mass spectral studies. The newly synthesized compounds were tested for their antimicrobial activity against two fungal species and two bacterial species. The obtained data indicated that some of the tested compounds exhibited both antibacterial and antifungal activities, particularly compounds 14, 16, 17 and 18 showed a comparable effect to a well known antibacterial and antifungal agent.
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M. A. El-Ebiary Nora, M. El-Telbani Emad, H. Swellem Randa, F. Zeid Ibrahim and A. M. Nawwar Galal, Design, Synthesis, Crystal Structure, and Antimicrobial Evaluation of Novel Pyrazolyl-1,3,5-oxadiazoles, Pyrazolyl-1,2,4-triazoles and their Related Thioglycosides, Letters in Drug Design & Discovery 2013; 10 (5) . https://dx.doi.org/10.2174/1570180811310050012
DOI https://dx.doi.org/10.2174/1570180811310050012 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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