Abstract
Periodontal diseases are common inflammatory conditions of the supporting apparatus of the teeth which lead to early tooth loss. This review discusses the evidence for a role of reactive oxygen species in inducing periodontal tissue damage and focuses on recent evidence showing increased local and systemic alterations in the redox balance of periodontitis. An appraisal of the methods for analysis of oxidative stress in periodontal disease research is provided, showing an increase in oxidative stress measures and oxidative damage fingerprints detected in studies investigating periodontitis cases compared to healthy controls. Hypotheses on the relationships between oxidative stress and inflammatory responses and on the role of redox status in periodontal medicine are discussed. Finally, the review provides an overview of possible intervention pathways for the use of antioxidants as adjuncts to mechanical biofilm removal for the treatment of periodontitis.
Keywords: Oxidative stress, antioxidant, periodontitis
Current Pharmaceutical Design
Title:Periodontitis and Redox Status: A Review
Volume: 19 Issue: 15
Author(s): Luigi Nibali and Nikos Donos
Affiliation:
Keywords: Oxidative stress, antioxidant, periodontitis
Abstract: Periodontal diseases are common inflammatory conditions of the supporting apparatus of the teeth which lead to early tooth loss. This review discusses the evidence for a role of reactive oxygen species in inducing periodontal tissue damage and focuses on recent evidence showing increased local and systemic alterations in the redox balance of periodontitis. An appraisal of the methods for analysis of oxidative stress in periodontal disease research is provided, showing an increase in oxidative stress measures and oxidative damage fingerprints detected in studies investigating periodontitis cases compared to healthy controls. Hypotheses on the relationships between oxidative stress and inflammatory responses and on the role of redox status in periodontal medicine are discussed. Finally, the review provides an overview of possible intervention pathways for the use of antioxidants as adjuncts to mechanical biofilm removal for the treatment of periodontitis.
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Cite this article as:
Nibali Luigi and Donos Nikos, Periodontitis and Redox Status: A Review, Current Pharmaceutical Design 2013; 19 (15) . https://dx.doi.org/10.2174/1381612811319150003
DOI https://dx.doi.org/10.2174/1381612811319150003 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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