Abstract
In this report, the authors review the human skeleton and the increasing burden of bone deficiencies, the limitations encountered with the current treatments and the opportunities provided by the emerging field of cell-based bone engineering. Special emphasis is placed on different sources of human progenitor cells, as well as their pros and cons in relation to their utilization for the large-scale construction of functional bone-engineered substitutes for clinical applications. It is concluded that, human pluripotent stem cells represent a valuable source for the derivation of progenitor cells, which combine the advantages of both embryonic and adult stem cells, and indeed display high potential for the construction of functional substitutes for bone replacement therapies.
Keywords: Adult stem cells, bone deficiencies, bone engineering, embryonic-derived progenitors, human embryonic stem cells, human skeleton, mesenchymal stem cells.
Current Molecular Medicine
Title:Human Progenitor Cells for Bone Engineering Applications
Volume: 13 Issue: 5
Author(s): G.M. de Peppo, P. Thomsen, C. Karlsson, R. Strehl, A. Lindahl and J. Hyllner
Affiliation:
Keywords: Adult stem cells, bone deficiencies, bone engineering, embryonic-derived progenitors, human embryonic stem cells, human skeleton, mesenchymal stem cells.
Abstract: In this report, the authors review the human skeleton and the increasing burden of bone deficiencies, the limitations encountered with the current treatments and the opportunities provided by the emerging field of cell-based bone engineering. Special emphasis is placed on different sources of human progenitor cells, as well as their pros and cons in relation to their utilization for the large-scale construction of functional bone-engineered substitutes for clinical applications. It is concluded that, human pluripotent stem cells represent a valuable source for the derivation of progenitor cells, which combine the advantages of both embryonic and adult stem cells, and indeed display high potential for the construction of functional substitutes for bone replacement therapies.
Export Options
About this article
Cite this article as:
Peppo G.M. de, Thomsen P., Karlsson C., Strehl R., Lindahl A. and Hyllner J., Human Progenitor Cells for Bone Engineering Applications, Current Molecular Medicine 2013; 13 (5) . https://dx.doi.org/10.2174/1566524011313050004
DOI https://dx.doi.org/10.2174/1566524011313050004 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Mitochondrial Dysfunction and Its Relationship with mTOR Signaling and Oxidative Damage in Autism Spectrum Disorders
Mini-Reviews in Medicinal Chemistry Effects of Physical Exercise on Depressive Symptoms and Biomarkers in Depression
CNS & Neurological Disorders - Drug Targets Clinical Evaluation of Anti-Obesity Drugs
Current Drug Targets Involvement of the Transforming Growth Factor β in the Pathogenesis of Hereditary Hemorrhagic Telangiectasia
Current Pharmaceutical Design An Update on Developments in Female Hormonal Contraception
Current Women`s Health Reviews Culture Duration-, Donor-, and Medium-Dependent Changes in OATP1B3- Mediated Telmisartan Uptake in Human Hepatocytes
Drug Metabolism Letters Exploring the Nucleolar Proteome: Novel Concepts for Chaperone Trafficking and Function
Current Proteomics Patent Selections:
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Lymphocyte Subsets in Patients with β-Thalassemia Major
Current Immunology Reviews (Discontinued) Exploring the Cardio-metabolic Relevance of T-cadherin: A Pleiotropic Adiponectin Receptor
Endocrine, Metabolic & Immune Disorders - Drug Targets Biocatalysis Applied to the Synthesis of Vitamin D Analogues
Current Organic Chemistry Pharmacologic Modulators of Soluble Guanylate Cyclase/Cyclic Guanosine Monophosphate in the Vascular System - From Bench Top to Bedside
Current Vascular Pharmacology A Novel Probiotic Formula, BIOCG, Protects Against Alzheimer’s-Related Cognitive Deficits via Regulation of Dendritic Spine Dynamics
Current Alzheimer Research Imbalance of Steroid Hormones in Hamsters Infected with <i>Schistosoma mansoni</i>
Endocrine, Metabolic & Immune Disorders - Drug Targets Restoration of Chemoresistance Mechanism by Novel Drug Therapies in Breast Cancer Cell Lines
Current Drug Therapy Biomarker Assessment in Nutritional Modulation of Oxidative Stress-Induced Cancer Development by Lipid-Related Bioactive Molecules
Recent Patents on Anti-Cancer Drug Discovery Vitamin D and Cardiovascular Disease
Current Vascular Pharmacology Angiogenesis and Angiogenesis Inhibitors: a New Potential Anticancer Therapeutic Strategy
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Cultured Adult Animal Neurons and Schwann Cells Give Us New Insights into Diabetic Neuropathy
Current Diabetes Reviews Are the Myokines the Mediators of Physical Activity-Induced Health Benefits?
Current Pharmaceutical Design