Acetylcholinesterase Inhibitors from QSAR Point of View: How Close are We?

Title:Acetylcholinesterase Inhibitors from QSAR Point of View: How Close are We?

Volume: 13 Issue: 1

Author(s): Anuradha Sharma and Poonam Piplani

Affiliation:

Keywords: Acetylcholinesterase inhibitors, computational predictions, docking approaches, molecular modeling, QSAR

Abstract: In view of the large libraries of acetylcholinesterase inhibitors (AChEIs) that are now being handled in organic synthesis, the identification of drug biological activity is advisable prior to synthesis and this can be achieved by employing predictive biological property methods. In this sense, Quantitative Structure–Activity Relationships (QSAR) or docking approaches have emerged as promising tools. The intention of this review is to summarize the present knowledge concerning computational predictions of AChEIs and AChE.

Cite this article as:

Sharma Anuradha and Piplani Poonam, Acetylcholinesterase Inhibitors from QSAR Point of View: How Close are We?, Central Nervous System Agents in Medicinal Chemistry 2013; 13 (1) . https://dx.doi.org/10.2174/1871524911313010009