Pseudomonas aeruginosa -Eukaryotic Cell Crosstalk: Mediators, Mechanisms and Implications for the Antimicrobial Therapy

Title:Pseudomonas aeruginosa -Eukaryotic Cell Crosstalk: Mediators, Mechanisms and Implications for the Antimicrobial Therapy

Volume: 17 Issue: 2

Author(s): Carmen Curutiu, Mariana Carmen Chifiriuc and Magda Mihaela Mitache

Affiliation:

Keywords: Autoinducers, Host-pathogen relationship, Immunomodulation, Inter-kingdom communication, Pseudomonas aeruginosa, Quorum sensing

Abstract: Bacteria commonly communicate with each other by a cell-to-cell signaling mechanism known as quorum sensing, using soluble mediators. Recent studies showed that these molecules target not only bacteria, but also interact with the eukaryotic host. Pseudomonas aeruginosa infection occurs both in acute or chronic states in a variety of respiratory and urinary infections. These infections are often difficult to treat, and numerous therapeutic options, besides antibiotics, have been searched. In this context quorum-sensing inhibitors could represent an attractive potential therapeutic strategy with promising results.

Cite this article as:

Curutiu Carmen, Carmen Chifiriuc Mariana and Mihaela Mitache Magda, Pseudomonas aeruginosa -Eukaryotic Cell Crosstalk: Mediators, Mechanisms and Implications for the Antimicrobial Therapy, Current Organic Chemistry 2013; 17 (2) . https://dx.doi.org/10.2174/1385272811317020011