Silver Nanoparticles in Cancer: Therapeutic Efficacy and Toxicity

C.      Ong; J.Z.Z.      Lim; C-T.      Ng; J.J.      Li; L-Y.L.      Yung; B-H.      Bay

doi:10.2174/0929867311320060003

Abstract

In recent years, there has been escalating interest in the biomedical applications of nanoparticles (NPs). In particular, silver nanoparticles (AgNPs) are increasingly being investigated as tools for novel cancer therapeutics, capitalizing on their unique properties to enhance potential therapeutic efficacy. However, questions as to are we able to contain or control the toxicity effects of AgNPs, and how much do we know about the toxicological profile of AgNPs which are commonly used in emerging nanotechnology-based applications, still remain. Hence, serious considerations have to be given to the hazards and risks of toxicity associated with the use of AgNPs. This review focuses on the current applications of AgNPs, their known effects and toxicity, as well as the potential of harnessing them for use in cancer therapy.

Keywords: Nanotechnology, nanomaterials, silver nanoparticles, biomedical applications, toxicity, in vitro approach, in vivo study, cancer therapy, cancer detection, antimicrobial agents