Adhesion of Osteoblasts to a Vertically Aligned TiO2 Nanotube Surface

Title:Adhesion of Osteoblasts to a Vertically Aligned TiO2 Nanotube Surface

Volume: 13 Issue: 2

Author(s): Ekaterina Gongadze, Doron Kabaso, Sebastian Bauer, Jung Park, Patrik Schmuki and Ales Iglic

Affiliation:

Keywords: TiO2 nanotube surfaces, adhesion, dynamic simulations, nanostructured surface topography, osteoblast adhesion

Abstract: The adhesion of cells to vertically aligned TiO2 nanotubes is reviewed. The attraction between a negatively charged nanotube surface and a negatively charged osteoblast is facilitated by charged protein-mediators like proteins with a quadrupolar internal charge distribution, fibronectin and vitronectin. It is shown that adhesion and spreading of osteoblasts on vertically aligned TiO2 nanotube surfaces depend on the diameter of the nanotubes. Apparently, a small diameter nanotube surface has on average more sharp convex edges per unit area than a large one, leading to stronger binding affinity on its surface.

Cite this article as:

Gongadze Ekaterina, Kabaso Doron, Bauer Sebastian, Park Jung, Schmuki Patrik and Iglic Ales, Adhesion of Osteoblasts to a Vertically Aligned TiO2 Nanotube Surface, Mini-Reviews in Medicinal Chemistry 2013; 13 (2) . https://dx.doi.org/10.2174/1389557511313020002