Abstract
The preparation of substituted piperidines via three-component reaction between aldehydes, aromatic amines and acetoacetic esters has been developed. The process has been carried out under ambient conditions in the presence of zinc hydrogen sulfate [Zn(HSO4)2]. A variety of aldehydes and amines were yielded into the corresponding products demonstrating the versatility of the reaction.
Keywords: Diastereoselectivity, functionalized piperidines, metal hydrogen sulfate, zinc hydrogen sulfate [Zn(HSO4)2], Donepezil, Sertindole, Risperidone, anti-inflammatory, anti-hypertensive, anti-convulsant
Letters in Organic Chemistry
Title:Zinc Hydrogen Sulfate Promoted Multi-component Preparation of Highly Functionalized Piperidines
Volume: 9 Issue: 7
Author(s): Majid Ghashang
Affiliation:
Keywords: Diastereoselectivity, functionalized piperidines, metal hydrogen sulfate, zinc hydrogen sulfate [Zn(HSO4)2], Donepezil, Sertindole, Risperidone, anti-inflammatory, anti-hypertensive, anti-convulsant
Abstract: The preparation of substituted piperidines via three-component reaction between aldehydes, aromatic amines and acetoacetic esters has been developed. The process has been carried out under ambient conditions in the presence of zinc hydrogen sulfate [Zn(HSO4)2]. A variety of aldehydes and amines were yielded into the corresponding products demonstrating the versatility of the reaction.
Export Options
About this article
Cite this article as:
Ghashang Majid, Zinc Hydrogen Sulfate Promoted Multi-component Preparation of Highly Functionalized Piperidines, Letters in Organic Chemistry 2012; 9 (7) . https://dx.doi.org/10.2174/157017812802139564
DOI https://dx.doi.org/10.2174/157017812802139564 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Sympathetic and Baroreflex Function in Hypertension: Implications for Current and New Drugs
Current Pharmaceutical Design Crystal Structures of Phosphodiesterases and Implications on Substrate Specificity and Inhibitor Selectivity
Current Topics in Medicinal Chemistry Side Effects of AAS Abuse: An Overview
Mini-Reviews in Medicinal Chemistry Impact of Cytochrome P450 2C19*2 and *3 on Clopidogrel Loading Dose in Saudi Patients with Acute Coronary Syndrome
Drug Metabolism Letters Heat Shock Proteins - Two Sides of a Coin
Current Cardiology Reviews Bilayer Tablet Based Chronotherapeutics in the Management of Nocturnal Asthma: An Overview
Recent Patents on Drug Delivery & Formulation The Role of Neopterin in Atherogenesis and Cardiovascular Risk Assessment
Current Medicinal Chemistry Effect of Black Seed on Dextromethorphan O- and N-Demethylation in Human Liver Microsomes and Healthy Human Subjects
Drug Metabolism Letters Apolipoprotein(a) in the Carotid Artery Plaque: Evidence for Proteolytic and Pro-Inflammatory Modifications
Vascular Disease Prevention (Discontinued) Systems Biology and Biomechanical Model of Heart Failure
Current Cardiology Reviews Monoclonal Antibody-Based Targeted Therapy in Breast Cancer
Current Medicinal Chemistry - Anti-Cancer Agents Subject Index to Volume 2
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Hyperuricaemia and Non-Alcoholic Fatty Liver Disease (NAFLD): A Relationship with Implications for Vascular Risk?
Current Vascular Pharmacology Advanced Nanomedicines for the Treatment and Diagnosis of Myocardial Infarction and Heart Failure
Current Drug Targets The Influence of Microneedles on the Percutaneous Penetration of Selected Antihypertensive Agents: Diltiazem Hydrochloride and Perindopril Erbumine
Current Drug Delivery Posterior Reversible Encephalopathy Syndrome with Atypical Presentation: A Pictorial Review on MR Imaging Features
Current Medical Imaging NADPH Oxidase and Neurodegeneration
Current Neuropharmacology The Repurposing of Old Drugs or Unsuccessful Lead Compounds by in Silico Approaches: New Advances and Perspectives
Current Topics in Medicinal Chemistry The Adrenergic System in Gastrointestinal Cancers
Current Cancer Therapy Reviews The Promising Pharmacological Effects and Therapeutic/Medicinal Applications of Punica Granatum L. (Pomegranate) as a Functional Food in Humans and Animals
Recent Patents on Inflammation & Allergy Drug Discovery