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Review Article

Engineering of Exosomes: Steps Towards Green Production of Drug Delivery System

Author(s): Abdelrahman Y. Sherif*, Gamaleldin I. Harisa, Fars K. Alanazi and Abdullah M.E. Youssof

Volume 20, Issue 15, 2019

Page: [1537 - 1549] Pages: 13

DOI: 10.2174/1389450120666190715104100

Price: $65

Abstract

Targeting of therapeutic agents to their specific site of action not only increases the treatment efficacy, but also reduces systemic toxicity. Therefore, various drug delivery systems (DDSs) have been developed to achieve this target. However, most of those DDSs have several issues regarding biocompatibility and environmental hazard. In contrast to the synthetic DDSs, exosome-based natural carriers are biocompatible, biodegradable and safe for the environment. Since exosomes play a role in intercellular communication, they have been widely utilized as carriers for different therapeutic agents. This article was aimed to provide an overview of exosomes as an environment-friendly DDS in terms of engineering, isolation, characterization, application and limitation.

Keywords: Drug targeting, biological DDS, green DDS, exosome, bionanocarrier, vesicular carrier.

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