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Review Article

NIR荧光在MDR癌症治疗中的作用：从靶向成像到光疗

卷 27, 期 33, 2020

页: [5510 - 5529] 页: 20

弟呕挨: 10.2174/0929867326666190627123719

价格: $65

摘要

背景：多药耐药性（MDR）被定义为癌细胞对各种化学疗法的交叉耐药性，并已证明与药物外排泵相关。药物外排泵的可视化对于预选可能对化疗不敏感的患者很有用，从而防止患者不必要的治疗。由于近红外（NIR）成像具有低的组织自发荧光和深层的组织穿透性，因此它是监视MDR的一种有吸引力的方法。 MDR癌症的分子NIR成像需要具有高特异性和亲和力的稳定靶向生物标志物的探针。 目的：本文旨在简要概述新型NIR探针及其在MDR癌症治疗中的应用。 结果：近来，已进行了广泛的研究以开发新型的NIR探针，几种策略显示出巨大的希望。这些策略包括NIR染料与靶向MDR相关的生物标记物的配体之间的化学共轭，具有固有靶向能力的天然NIR染料，可活化的NIR探针以及装有NIR染料的纳米粒子。此外，NIR探针已广泛用于癌症治疗中的光热和光动力疗法，与其他方式相结合以克服MDR。随着纳米技术的迅速发展，各种纳米颗粒都与NIR染料结合在一起，为控制药物输送和抗MDR的联合疗法提供了多功能平台。将讨论针对NDR成像和光疗的MDR癌症探针的构建。集成了MDR监测和联合疗法的多峰纳米级平台也将包括在内。 结论：我们相信这些NIR探针为MDR癌症的诊断和治疗提供了一种有前途的方法，因此具有在癌症治疗中达到临床应用的巨大潜力。

关键词: 分子成像，近红外染料，多药耐药性，P-糖蛋白，探针，光疗。

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