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Review Article

蛋白质相互作用域和翻译后修饰:结构特征和药物发现的应用

卷 27, 期 37, 2020

页: [6306 - 6355] 页: 50

弟呕挨: 10.2174/0929867326666190620101637

价格: $65

摘要

背景：健康细胞和/或与疾病发生和进展有关的许多途径依赖于包括多蛋白复合物在内的大的集合。蛋白质-蛋白质的相互作用可能通过称为蛋白质相互作用域(PIDs)的大量模块发生。 目的：这篇综述关注的是PIDs识别翻译后修饰肽序列，旨在为科学界提供其三维结构、结合拓扑和药物发现领域的潜在应用的最新知识。 方法：通过搜索Pfam (Protein family)、SMART (Simple Modular Architecture Research Tool)和PDB (Protein Data Bank)等数据库，寻找不同的结构域家族，并获得涉及特定PID的蛋白复合物的结构信息。通过Pubmed检索并分析了最近有关PIDs和相关药物发现运动的文献。 结果和结论：在绑定首选项方面，PID是通用的。它们中的许多只识别特定的经翻译后修饰的氨基酸片段，其他一些能够与几个翻译后修饰的序列或未修饰的序列相互作用。许多PID可能与包括癌症在内的不同疾病有关。大量可用的结构数据导致了基于结构设计的若干分子靶向肽介导的蛋白质-蛋白质相互作用，包括肽、肽化学和小化合物。在不同的家族中，需要更多的研究来充分发挥作为可靠治疗靶点的磷脂酰亚胺，但是，攻击磷脂酰亚胺而不是特定蛋白的催化结构域可能是获得选择性抑制剂的途径。

关键词: 蛋白质结合模块，翻译后修饰，多肽，小分子，结合位点，结构生物学，药物发现

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