Abstract
The advent of genomics approaches to studying human disease have yielded a large number of genes and gene families that are involved in the process of bone formation and bone remodeling. The identification and characterization of these genes has provided significant insights into the pathogenesis of numerous human bone diseases. This review details current understanding of the role of many of these genes in bone development and disease. We review the current status of bone disease prevention/treatment modalities and describe how recent advances in our understanding of the molecules responsible for different aspects of osteoblast, osteoclast and chondrocyte function may provide novel biochemical markers and treatment strategies for bone disease.
Keywords: Bone Disease, Aromatase Deficieny, linked dominant Conradi-Hunermann, Down Syndrome skeletal abnormalities, Ellis-van Creveld syndrome, Crouzon syndrome, Apert syndrome, Pfeiffer syndrome, multiple epiphyseal dysplasia (MED), achondroplasia
Current Genomics
Title: Bone Disease - Current Knowledge and Future Prospects
Volume: 2 Issue: 2
Author(s): Francesca Lazner, Ernst Wolvetang, Daniel Lazner and Paul Hertzog
Affiliation:
Keywords: Bone Disease, Aromatase Deficieny, linked dominant Conradi-Hunermann, Down Syndrome skeletal abnormalities, Ellis-van Creveld syndrome, Crouzon syndrome, Apert syndrome, Pfeiffer syndrome, multiple epiphyseal dysplasia (MED), achondroplasia
Abstract: The advent of genomics approaches to studying human disease have yielded a large number of genes and gene families that are involved in the process of bone formation and bone remodeling. The identification and characterization of these genes has provided significant insights into the pathogenesis of numerous human bone diseases. This review details current understanding of the role of many of these genes in bone development and disease. We review the current status of bone disease prevention/treatment modalities and describe how recent advances in our understanding of the molecules responsible for different aspects of osteoblast, osteoclast and chondrocyte function may provide novel biochemical markers and treatment strategies for bone disease.
Export Options
About this article
Cite this article as:
Lazner Francesca, Wolvetang Ernst, Lazner Daniel and Hertzog Paul, Bone Disease - Current Knowledge and Future Prospects, Current Genomics 2001; 2 (2) . https://dx.doi.org/10.2174/1389202013351048
DOI https://dx.doi.org/10.2174/1389202013351048 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Risk Scores for Patients with Chest Pain: Evaluation in the Emergency Department
Current Cardiology Reviews Progress of Biological Agents on Psoriatic Arthritis
Current Pharmaceutical Biotechnology Synthesis and Biological Evaluation of Atorvastatin Derivatives as Novel HMG-CoA Reductase Inhibitors
Letters in Drug Design & Discovery Diabetes Mellitus, Hypertension and Hypercholesterolemia in Relation to the 10-Year ACS Prognosis; the GREECS Study
Current Vascular Pharmacology Statins Attenuate Fibrotic Manifestations of Cardiac Tissue Damage
Current Molecular Pharmacology Recent Advances in Hematopoietic Stem Cell-Mediated Regeneration
Recent Patents on Regenerative Medicine UKPDS Risk Engine, Decode and Diabetes PHD Models for the Estimation of Cardiovascular Risk in Patients with Diabetes
Current Diabetes Reviews Does the Immune System Regulate Mood to Defend against Infection? Evidence from Studies of Immune Factors, Depression, and Antidepressants
Current Psychiatry Reviews The Role of Fibrate Treatment in Dyslipidemia: An Overview
Current Pharmaceutical Design Relationships between Serotoninergic System and Skin Fibrotic
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Fluoride Effects: The Two Faces of Janus
Current Medicinal Chemistry Therapy Of Cardiac Arrhythmias In Children: An Emerging Role Of Electroanatomical Mapping Systems
Current Vascular Pharmacology Epigenetic Basis of Individual Variability to Major Psychosis
Current Pharmacogenomics and Personalized Medicine Prevalence of Diabetes Among Immigrants in the Nordic Countries
Current Diabetes Reviews HIF Inhibitors: New Hope for Cancer Therapy
Letters in Drug Design & Discovery Epoxide Hydrolases and their Application in Organic Synthesis
Current Organic Chemistry Control of Blood Pressure in the Community: An Unsolved Problem
Current Pharmaceutical Design Microbial Biotransformation: Recent Developments on Steroid Drugs
Recent Patents on Biotechnology Chemokines: Central Mediators of the Innate Response to Sepsis
Current Immunology Reviews (Discontinued) Update on Medical and Surgical Management of Intracerebral Hemorrhage
Reviews on Recent Clinical Trials