Recent Study of Dual HDAC/PARP Inhibitor for the Treatment of Tumor

Haiying       Lu; Lan       Bai; Yanping       Zhou; Yongping       Lu; Zhongliang       Jiang; Jianyou       Shi
doi:10.2174/1568026619666190603092407
Abstract

The occurrence and development of tumors are closely related to epigenetic instability which modulates gene expression through DNA methylation, histone modification, chromatin remodeling, and RNA-related silencing. Histone deacetylase (HDAC) and poly (ADP-ribose) polymerase (PARP) are targets of epigenetic regulation. Over the years, a large number of studies have shown that HDAC inhibitors and PARP inhibitors have synergistic effects in the treatment of tumors, and there are reports of related dual HDAC/PARP inhibitors. This review will give a brief summary of the synergistic mechanisms of HDAC inhibitors and PARP inhibitors and introduce the design of the first dual HDAC/PARP inhibitor, which may guide the design of more dual HDAC/PARP inhibitors for the treatment of tumors.
Keywords: Epigenetics, Tumor, HDAC, PARP, Dual inhibitors, Synergy.
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DOI https://dx.doi.org/10.2174/1568026619666190603092407	Print ISSN 1568-0266
Publisher Name Bentham Science Publisher	Online ISSN 1873-4294
Current Topics in Medicinal Chemistry

Recent Study of Dual HDAC/PARP Inhibitor for the Treatment of Tumor

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