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Research Article

抑制SOX15使食管鳞状细胞癌细胞对紫杉醇敏感

卷 19, 期 5, 2019

页: [349 - 356] 页: 8

弟呕挨: 10.2174/1566524019666190405121139

价格: $65

摘要

背景：SOX15是参与胚胎发育调控和细胞命运决定的关键转录因子。它也是癌症中肿瘤发生的重要介质。 方法：在此，我们寻求探索SOX15在食管鳞状细胞癌（ESCC）中的表达模式和生物学功能。发现SOX15在ESCC肿瘤中异常过表达。 结果：在实验上，通过RNAi抑制SOX15抑制了ESCC细胞中的细胞增殖，并使癌细胞对紫杉醇敏感，但对顺铂没有敏感。此外，SOX15的抑制显着抑制与WNT和NOTCH信号传导途径相关的基因的表达，这可能有助于增加对紫杉醇的敏感性。 结论：总之，目前的研究表明，ESCC细胞中SOX15的抑制使ESCC细胞对紫杉醇敏感，这表明SOX15表达水平可预测紫杉醇治疗ESCC的治疗效果。

关键词: SOX15，ESCC，紫杉醇，RNAi，WNT，NOTCH。

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[1]
Wei WQ, Yang J, Zhang SW, Chen WQ, Qiao YL. Esophageal cancer mortality trends during the last 30 years in high risk areas in China: comparison of results from national death surveys conducted in the 1970‘s, 1990’s and 2004-2005. Asian Pac J Cancer Prev 2011; 12(7): 1821-6.
[2]
Song QK, Li J, Jiang HD, He YM, Zhou XQ, Huang CY. Esophageal cancer mortality during 2004-2009 in Yanting County, China. Asian Pac J Cancer Prev 2012; 13(10): 5003-6.
[3]
Cancer Genome Atlas Research N, Analysis Working Group: Asan U, Agency BCC, Brigham, Women's H, Broad I, et al Integrated genomic characterization of oesophageal carcinoma. Nature 2017; 541(7636): 169-75.
[4]
Hu N, Kadota M, Liu H, et al. Genomic Landscape of Somatic Alterations in Esophageal Squamous Cell Carcinoma and Gastric Cancer. Cancer Res 2016; 76(7): 1714-23.
[5]
Kalatskaya I. Overview of major molecular alterations during progression from Barrett’s esophagus to esophageal adenocarcinoma. Annals of the New York Academy of Sciences 2016; 1381(1): 74-91.
[6]
Sasaki Y, Tamura M, Koyama R, Nakagaki T, Adachi Y, Tokino T. Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing. World J Gastroenterol 2016; 22(7): 2284-93.
[7]
Kotecki N, Hiret S, Etienne PL, et al. First-Line Chemotherapy for Metastatic Esophageal Squamous Cell Carcinoma: Clinico-Biological Predictors of Disease Control. Oncology 2016; 90(2): 88-96.
[8]
Lagergren J, Lagergren P. Oesophageal cancer. BMJ 2010; 341: c6280.
[9]
Lee HJ, Goring W, Ochs M, et al. Sox15 is required for skeletal muscle regeneration. Mol Cell Biol 2004; 24(19): 8428-36.
[10]
Sarraj MA, Wilmore HP, McClive PJ, Sinclair AH. Sox15 is up regulated in the embryonic mouse testis. Gene Expr Patterns 2003; 3(4): 413-7.
[11]
Beranger F, Mejean C, Moniot B, Berta P, Vandromme M. Muscle differentiation is antagonized by SOX15, a new member of the SOX protein family. J Biol Chem 2000; 275(21): 16103-9.
[12]
Moradi A, Ghasemi F, Anvari K, et al. The cross-regulation between SOX15 and Wnt signaling pathway. J Cell Physiol 2017; 232(12): 3221-5.
[13]
Thu KL, Radulovich N, Becker-Santos DD, et al. SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/beta-catenin signaling. Oncogene 2014; 33(3): 279-88.
[14]
Sulahian R, Chen J, Arany Z, et al. SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas Cell Mol Gastroenterol Hepatol. 2015; 1(6): 598-609 e6..
[15]
Guo F, Yan L, Guo H, et al. The transcriptome and DNA methylome landscapes of human primordial germ cells. Cell 2015; 161(6): 1437-52.
[16]
Xie SL, Fan S, Zhang SY, et al. SOX8 regulates cancer stem-like properties and cisplatin-induced EMT in tongue squamous cell carcinoma by acting on the Wnt/beta-catenin pathway. Int J Cancer 2018; 142(6): 1252-65.
[17]
Kolenda J, Jensen SS, Aaberg-Jessen C, et al. Effects of hypoxia on expression of a panel of stem cell and chemoresistance markers in glioblastoma-derived spheroids. J Neurooncol 2011; 103(1): 43-58.
[18]
Garros-Regulez L, Aldaz P, Arrizabalaga O, et al. mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance. Expert Opin Ther Targets 2016; 20(4): 393-405.
[19]
Chikazawa N, Tanaka H, Tasaka T, et al. Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells. Anticancer Res 2010; 30(6): 2041-8.
[20]
Flores ML, Castilla C, Gasca J, et al. Loss of PKCdelta Induces Prostate Cancer Resistance to Paclitaxel through Activation of Wnt/beta-Catenin Pathway and Mcl-1 Accumulation. Mol Cancer Ther 2016; 15(7): 1713-25.
[21]
Zhang K, Song H, Yang P, et al. Silencing dishevelled-1 sensitizes paclitaxel-resistant human ovarian cancer cells via AKT/GSK-3beta/beta-catenin signalling. Cell Prolif 2015; 48(2): 249-58.
[22]
Fischer MM, Cancilla B, Yeung VP, et al. WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death. Sci Adv 2017; 3(6): e1700090.
[23]
Kang H, Jeong JY, Song JY, et al. Notch3-specific inhibition using siRNA knockdown or GSI sensitizes paclitaxel-resistant ovarian cancer cells. Mol Carcinog 2016; 55(7): 1196-209.
[24]
Wang Z, Li Y, Ahmad A, et al. Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochim Biophys Acta 2010; 1806(2): 258-67.
[25]
Rahman MT, Nakayama K, Rahman M, et al. Notch3 overexpression as potential therapeutic target in advanced stage chemoresistant ovarian cancer. Am J Clin Pathol 2012; 138(4): 535-44.

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