Abstract
Throughout our evolution, the importance of natural products for medicine and health has been increasing and it continues to be a key source of novel anticancer drugs, leads and new chemical entities. Among natural products, tricyclic heteroaromatic alkaloids such as carbazoles are an important class of natural and semi-synthetic organic compounds. In the last few decades medicinal role of natural and semi-synthetic carbazoles has expanded significantly, especially as a vital heterocyclic class of antitumor agents. Some of the carbazoles that displayed potential anticancer activity have undergone clinical trials. However, complications arising due to multidrug resistance in clinical trials led to very few of the selected carbazoles being approved for cancer therapy. Planar, polycyclic and aromatic carbazoles exhibit anticancer activity via DNA intercalation. Further many carbazoles can be cytotoxic by inhibiting DNA-dependent enzymes such as telomerase and topoisomerase I/II.
Keywords: Anticancer agent, antitumor agent, carbazole alkaloids, review.
Graphical Abstract
Anti-Cancer Agents in Medicinal Chemistry
Title:Current Perspective of Natural Alkaloid Carbazole and its Derivatives as Antitumor Agents
Volume: 15 Issue: 8
Author(s): Mahamadhanif S. Shaikh, Rajshekhar Karpoormath, Neeta Thapliyal, Rajesh A. Rane, Mahesh B. Palkar, A.M. Faya, Harun M. Patel, Wesam S. Alwan, Kavita Jain and Girish A. Hampannavar
Affiliation:
Keywords: Anticancer agent, antitumor agent, carbazole alkaloids, review.
Abstract: Throughout our evolution, the importance of natural products for medicine and health has been increasing and it continues to be a key source of novel anticancer drugs, leads and new chemical entities. Among natural products, tricyclic heteroaromatic alkaloids such as carbazoles are an important class of natural and semi-synthetic organic compounds. In the last few decades medicinal role of natural and semi-synthetic carbazoles has expanded significantly, especially as a vital heterocyclic class of antitumor agents. Some of the carbazoles that displayed potential anticancer activity have undergone clinical trials. However, complications arising due to multidrug resistance in clinical trials led to very few of the selected carbazoles being approved for cancer therapy. Planar, polycyclic and aromatic carbazoles exhibit anticancer activity via DNA intercalation. Further many carbazoles can be cytotoxic by inhibiting DNA-dependent enzymes such as telomerase and topoisomerase I/II.
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Shaikh S. Mahamadhanif, Karpoormath Rajshekhar, Thapliyal Neeta, Rane A. Rajesh, Palkar B. Mahesh, Faya A.M., Patel M. Harun, Alwan S. Wesam, Jain Kavita and Hampannavar A. Girish, Current Perspective of Natural Alkaloid Carbazole and its Derivatives as Antitumor Agents, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (8) . https://dx.doi.org/10.2174/1871520615666150113105405
DOI https://dx.doi.org/10.2174/1871520615666150113105405 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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