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Review Article

微生物群、免疫系统和自闭症谱系障碍疾病:一种面向新治疗方案的综合模式

卷 27, 期 31, 2020

页: [5119 - 5136] 页: 18

弟呕挨: 10.2174/0929867326666190328151539

价格: $65

摘要

背景：自闭症谱系障碍(ASD)是一种与遗传倾向和家族聚集密切相关的疾病。在ASD患者中，可以检测到不同程度的症状严重程度，文献中也知道ASD前驱者的近亲中存在中度自闭症表型。近年来，环境因素在调节基因组风险与ASD的发生、严重程度之间的关系中发挥的作用越来越受到人们的关注。在这一框架下，越来越多的证据强调了肠道菌群和炎症在神经发育病理生理学中的可能作用。本文的目的是回顾有关微生物群失调、炎症和ASD之间联系的发现。 方法：在PUBMED和谷歌学者数据库中检索查找1990年至2018年的文章，关键词组合为:微生物群、免疫系统、炎症、ASD、自闭症、广泛自闭症表型、成人。 结果：最近的证据表明，微生物群的改变、免疫系统和神经发育可能是深深交织在一起的，在生命早期相互塑造。然而，动物模型和人类样本的结果仍然是异质性的，很少有研究集中在成人患者和ASD中间表型。 结论：更好的理解这些途径,在一个综合框架核心与外围系统之间,可能不仅对自闭症症状的神经基础,阐明大脑病理生理学,而且它可能也会对仍然缺乏可用的治疗方法从而允许开发治疗这些疾病的新策略。

关键词: 自闭症谱系障碍，肠道微生物群，免疫系统，炎症，肠-脑轴，神经发育

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