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General Review Article

基于新型阿片受体的新型治疗的治疗潜力

卷 27, 期 12, 2020

页: [2012 - 2020] 页: 9

弟呕挨: 10.2174/0929867326666190121142459

价格: $65

摘要

简介：与μ阿片受体相似，中枢神经系统或周围组织中也存在κ阿片受体（KOR）。近年来，几种能够与KOR相互作用的分子因其在慢性疼痛，抑郁症，自身免疫性疾病和神经系统疾病中的治疗潜力而成为基础研究的重点。 讨论：讨论了KOR系统的作用以及因其激活或抑制而产生的临床效果。除慢性疼痛外，本文还介绍了它们在压力和药物复发情况下的潜在治疗用途，包括可能在药物成瘾中使用KORagonists。此外，提出了KOR-拮抗剂，KOR-激动剂和外周KOR-激动剂的潜在作用。 结论：除了疼痛以外，KOR还具有调节奖励和情绪的作用。由于其位置，KOR似乎介导了精神疾病，成瘾和抑郁之间的相互作用。在动物模型中进行的实验研究已经确定了可能有助于阐明特定病理生理过程的脑机制。

关键词: Kappa受体，阿片类药物，镇痛，抑郁，成瘾，压力，药物。

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