A Novel Approach to Predict Protein-Protein Interactions Related to Alzheimers Disease Based on Complex Network

Jie      Yang; Xiong-Fei      Jiang

doi:10.2174/092986610790780323

Abstract

A protein domain interaction prediction program was complied using C++ to predict whether a query protein could interact with other hub proteins. It is indicated that the proteins interacting with AATF (Apoptosis-Antagonizing Transcription Factor) possess a common conservative pattern: I-x(0,1)-E-x(2)-[A/E/N/T]-x-[E/K]. Our method is attempted to integrate the characteristics of protein interaction network with the simplest building blocks-conservative patterns.

Keywords: AD associated protein interaction network, signal pathway, conservative interaction pattern

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