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General Review Article

结核分枝杆菌中的生物素生物合成途径是开发抗菌剂的有效靶点

卷 27, 期 25, 2020

页: [4194 - 4232] 页: 39

弟呕挨: 10.2174/0929867326666190119161551

价格: $65

摘要

结核分枝杆菌（TB）仍然是导致全球传染病死亡的首要原因，仅由一种传染病引起，2016年估计死亡170万人。生物素是结核分枝杆菌中脂类生物合成和糖异生所必需的重要辅因子。 结核分枝杆菌依靠从新生物素生物合成来获得这种重要的辅因子，因为它不能从哺乳动物宿主中清除足够的生物素。 结核分枝杆菌中的生物素生物合成途径已得到充分研究，并经过严格的遗传方法验证，为药物化学工作提供了坚实的基础。 这篇综述检查了生物素生物合成和连接中涉及的酶的机制和结构，总结了该途径的遗传验证研究，然后分析了从基于结构的药物设计和表型筛选中获得的最有希望的抑制剂和天然产物。

关键词: 结核，传染病，结核分枝杆菌，生物素，生物合成，酶学，抗生素。

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