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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Research Article

B Lymphocytes Are Predictors of Insulin Resistance in Women with Gestational Diabetes Mellitus

Author(s): Yan Zhuang, Jin Zhang, Yiwei Li, Hongqin Gu, Jinyan Zhao, Ya Sun, Rencheng Wang, Chunyan Zhang, Wen Chen, Jianrong Weng, Lan Qi, Huifang Lu, Jiarong Zhang, Qin Liu, Yinyan He* and Xianming Xu

Volume 19, Issue 3, 2019

Page: [358 - 366] Pages: 9

DOI: 10.2174/1871530319666190101130300

Abstract

Backgroud: The present study aimed to investigate the association between immune cells and gestational diabetes mellitus (GDM) and identify a reasonable predictor of insulin resistance in women with GDM.

Objective: The clinical and biochemical characteristics of 124 women with GDM and 168 healthy pregnant women were compared.

Methods: The percentage of immune cells in the blood of the subjects was analyzed by flow cytometry. Pearson’s correlation analysis revealed the correlation between the percentage of B lymphocytes and insulin resistance. A cutoff point was determined for the percentage of B lymphocytes, based on insulin resistance, using receiver operating characteristic (ROC) curves.

Results: Compared to the healthy pregnant women, the percentages of B lymphocytes and IgA produced by B-cells were significantly different in women with GDM. The percentage of B lymphocytes was positively related to insulin resistance.The number of 14.05% of B lymphocytes was an optimal cutoff point that predicted the insulin resistance in women with GDM.

Conclusion: The percentage of B lymphocytes was positively associated with insulin resistance, and hence, might serve as an appropriate predictor of insulin resistance in women with GDM.

Keywords: B lymphocytes, insulin resistance, inflammation, GDM, immune, IgA, flow cytometry.

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