摘要
背景：热休克蛋白（HSPs）是主要的分子伴侣，它们积极参与蛋白质折叠;这对于在各种压力条件下保护蛋白质的结构和功能至关重要。虽然HSP具有重要的生理作用，但它们在各种致病条件如癌发生中的作用众所周知;然而，有限的文献已巩固其作为抗转移药物靶标的潜力。 目的：本综述概述了不同HSP对癌症进展和转移的作用;还讨论了HSP抑制剂作为抗肿瘤剂的可能作用。 方法：数据来自PubMed / Medline和其他知名期刊数据库。然后省略了过于陈旧且对评价没有重要作用的文献。 结果：尽管HSP具有强大的生理功能，但它们被认为是癌症预后和诊断的良好标志物。他们控制癌症的存活，增殖和进展事件，包括耐药性，转移和血管生成。由于肿瘤细胞更依赖于HSP的存活和增殖，因此HSP靶向抗癌药物的选择性和特异性仍然很高。这使得各种HSP成为癌症预防的潜在临床和实验目标。一系列HSP抑制剂已经在试验中，并且许多其他HSP抑制剂在实验条件下作为抗癌剂和抗转移剂。通过调节HSP，还研究了几种天然产物对抗癌和抗转移剂的功效。 结论：除了作为抗癌药物靶标的作用外，HSPs已被证明是预防癌症进展的有希望的靶标。 使用这些分子作为抗转移剂需要广泛的研究。 该系列的进一步研究可以产生特异性和有效的抗转移剂。
关键词: 热休克蛋白，癌症，转移，上皮至间充质转换，HSP抑制剂，天然产物。
图形摘要
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