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Review Article

血红蛋白在医学上用于释放外源性一氧化碳

卷 27, 期 18, 2020

页: [2949 - 2963] 页: 15

弟呕挨: 10.2174/0929867325666181113122340

价格: $65

摘要

低浓度的一氧化碳(CO)对机体有多种积极作用，包括抗凋亡、抗炎、抗氧化和抗增殖作用。虽然CO作为一种有效的医用生物活性气体有很大的潜力，但它要在体内以稳定的形式存在，就必须有载体。血红蛋白(Hb)是一种很有希望用作CO载体的物质，因为体内大部分的CO都与血红蛋白一起储存在红细胞中。已经尝试开发一种使用RBC和HB-based人工氧载体的基于hbco的携带系统。据报道，其中一些作为CO供体在临床前和临床研究中是安全的，并具有治疗价值。在这篇综述中，我们根据目前可用的文献证据，综述了基于RBC和hbr的人工氧载体作为CO载体在药物治疗顽固性疾病方面的潜力。

关键词: 血红蛋白，一氧化碳，红细胞，血红蛋白为基础的氧载体，抗增殖作用，抗凋亡。

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