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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Role of Carbon Monoxide in Vascular Diseases

Author(s): Ignazio Barbagallo, Giuseppina Marrazzo, Alessandro Frigiola, Agata Zappala and Giovanni Li Volti

Volume 13, Issue 6, 2012

Page: [787 - 796] Pages: 10

DOI: 10.2174/138920112800399086

Price: $65

Abstract

During the degradation of heme by the enzyme heme oxygenase (HO), Carbon monoxide (CO) is generated. Although it is considered as a non - significant and potentially toxic waste gas of heme catabolism, CO is a key signaling molecule used to regulate different cardiovascular functions. In this review, we focus the protective roles of CO in vascular injury/disease, which may be important to explore the overall protective roles of HO-1/CO system in the pathogenesis of human vascular disease.

Keywords: Carbon monoxide, Heme oxygenase, oxidative stress, hypertension, vascular diseases


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