Abstract
Biaryls are a key structural motif in compounds with various applications, ranging from pharmaceuticals to material science, including ligands for organic synthesis. Given the growing concern about the use of transition metals in organic synthesis in terms of reaction condition mildness, substituents tolerance, reagents costs and toxicity, and purification of the products from metal traces, several alternatives have been developed to overcome the limitations of metal-catalyzed biaryls synthesis. Herein, we review the transition metal-free approaches to biaryls, which can be divided into metal-free crosscoupling of aromatics and metal-free benzannulation of aryl-substituted chains, as both fields have shown an impressive growth in recent years.
Keywords: Biaryls, metal-free, cross-coupling, diels-alder, annulation, oxidative coupling.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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