Abstract
Heterocycles are cyclic compounds with one or more heteroatom in their structures. They have various pharmaceutical applications. Incorporation of ferrocene scaffold into heterocyclic compounds can change the chemical and physiochemical properties of compounds. Ferrocene derivatives have a significant importance in pharmaceutical sciences like antibacterial, anticancer, antifungal, antiparasitic drug candidates, etc. Multicomponent reactions lead to simple and rapid procedures for the synthesis of organic compounds with molecular diversity. Multicomponent reactions have been used widely in heterocyclic synthesis, pharmaceutical chemistry, natural product synthesis, combinatorial chemistry, and polymer chemistry in the past two decades. This review deals with the synthesis of ferrocene-based heterocycles by multicomponent reactions.
Keywords: Multicomponent reactions, ferrocene, heterocycles, isocyanide, ferrocenecarbaldehyde, azetidine.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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