Abstract
In Drosophila, Sprouty was originally identified as an antagonist of tracheal branching and shown to be a general inhibitor of receptor tyrosine kinase. Recently, four mammalian homologues have been isolated. All Sprouty proteins exhibit a unique, highly conserved, cysteinerich C-terminal domain. Genetic and biochemical data indicate that Sprouty proteins antagonize receptor tyrosine kinase signaling through specific inhibition of the Ras / Raf / MAP Kinase pathway by preventing Ras activation. Expression of sprouty genes is regulated by FGF in a negative autoregulatory loop and is localized to known domains of FGF signaling in the developing embryo. Overexpression studies suggest that vertebrate sprouty genes may be important regulators of several developmental processes. In particular, sprouty may play a role during the branching morphogenesis involved in angiogenesis, or the formation of the lung and the kidney, but also during gastrulation or limb formation.
Keywords: sprouty protein, receptor tyrosine kinase, sprouty gene
Current Genomics
Title: Sprouty Proteins, A New Family of Receptor Tyrosine Kinase Inhibitors
Volume: 3 Issue: 4
Author(s): Isabelle Gross and Jonathan D. Licht
Affiliation:
Keywords: sprouty protein, receptor tyrosine kinase, sprouty gene
Abstract: In Drosophila, Sprouty was originally identified as an antagonist of tracheal branching and shown to be a general inhibitor of receptor tyrosine kinase. Recently, four mammalian homologues have been isolated. All Sprouty proteins exhibit a unique, highly conserved, cysteinerich C-terminal domain. Genetic and biochemical data indicate that Sprouty proteins antagonize receptor tyrosine kinase signaling through specific inhibition of the Ras / Raf / MAP Kinase pathway by preventing Ras activation. Expression of sprouty genes is regulated by FGF in a negative autoregulatory loop and is localized to known domains of FGF signaling in the developing embryo. Overexpression studies suggest that vertebrate sprouty genes may be important regulators of several developmental processes. In particular, sprouty may play a role during the branching morphogenesis involved in angiogenesis, or the formation of the lung and the kidney, but also during gastrulation or limb formation.
Export Options
About this article
Cite this article as:
Gross Isabelle and Licht D. Jonathan, Sprouty Proteins, A New Family of Receptor Tyrosine Kinase Inhibitors, Current Genomics 2002; 3 (4) . https://dx.doi.org/10.2174/1389202023350408
DOI https://dx.doi.org/10.2174/1389202023350408 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Screening Strategies to Identify New Antibiotics
Current Drug Targets Editorial
Current Bioactive Compounds Phytochemicals as Potential Curative Agents against Viral Infection: A Review
Current Organic Chemistry COVID-19 Pandemic and the Impact on the Cardiovascular Disease Patient Care
Current Cardiology Reviews Memantine Treatment in Patients with Mild to Moderate Alzheimers Disease Already Receiving a Cholinesterase Inhibitor: A Randomized, Double-Blind, Placebo-Controlled Trial
Current Alzheimer Research Helicobacter pylori Eradication Improves the Malnutrition, Inflammation and Atherosclerosis Syndrome in Peritoneal Dialysis Patients
Vascular Disease Prevention (Discontinued) Immunomodulation in Polytrauma and Polymicrobial Sepsis - Where Do We Stand?
Recent Patents on Inflammation & Allergy Drug Discovery Hot Melt Extrusion and its Application in 3D Printing of Pharmaceuticals
Current Drug Delivery Pharmacological Properties and Therapeutic Potential of Naringenin: A Citrus Flavonoid of Pharmaceutical Promise
Current Pharmaceutical Design Extended-spectrum Beta-lactamase Production in Pseudomonas aeruginosa and Acinetobacter baumannii Strains: Epidemiology, Molecular Characterization and Novel Proteomics-based Diagnostic Tools
Current Proteomics Catalytic Activity of Certain Antibodies as a Potential Tool for Drug Synthesis and for Directed Prodrug Therapies
Current Medicinal Chemistry Patent Review
Combinatorial Chemistry & High Throughput Screening Influence of Vanin-1 and Catalytic Products in Liver During Normal and Oxidative Stress Conditions
Current Medicinal Chemistry Neuropsychiatric Symptoms and Functional Status in Alzheimer’s Disease and Vascular Dementia Patients
Current Alzheimer Research Mechanisms of Thrombosis, Available Treatments and Management Challenges Presented by Thromboangiitis Obliterans
Current Medicinal Chemistry PDE5 Inhibitors in Non-Urological Conditions
Current Pharmaceutical Design Biological and Pharmacological Activities of Iridoids: Recent Developments
Mini-Reviews in Medicinal Chemistry Taking Risk Prediction to the Next Level. Advances in Biomarker Research for Atherosclerosis
Current Pharmaceutical Design Diabetic Gastroenteropathy: Soothe the Symptoms or Unravel a Cure?
Current Diabetes Reviews Protease Inhibitor Monotherapy as Maintenance Regimen in Patients With HIV Infection
Current HIV Research