Abstract
Background: Despite the successes achieved recently in the treatment of various infectious diseases, the morbidity and mortality associated with malaria remain major burdens.
Objective: The main limitations of conventional malaria therapy are the development of multi-drug resistance resulting in high dosage of different drugs and subsequent pill burden and toxicity. Thus, new effective antimalarial agents are urgently needed due to the increasing drug resistance of Plasmodium sp.
Discussion: Nature is successful in providing mankind with compounds against infectious diseases. Many of small drugs on the market were originally developed from natural-based compounds. Scaffolds, such as monoor diazanaphthalenes, naphthoquinone, indole, pyrrole or endoperoxides can be considered as privileged structures for the discovery of new antimalarials. Nevertheless, some difficulties associated with natural lead compounds derived from these scaffolds, such as their synthesis, limited aqueous solubility, chemical or metabolic instability and wide spectrum of biological effects are needed to be solved.
Conclusion: Thus, semisynthetic or synthetic analogues of natural antimalarial agents exhibiting optimized physicochemical properties, more selective biological activity and/or higher potency especially against resistant or multidrug resistant strains have been designed. The review is focused on selected recently reported potential antimalarial agents derived from isolated bioactive natural compounds based on the above-mentioned scaffolds. Their mechanism of action and structure-activity relationships are briefly mentioned.
Keywords: Antimalarials, natural products, quinoline, quinolone, quinazoline, indole, pyrrole, naphthoquinone, endoperoxides.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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