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Review Article

帕金森氏病药物替代疗法的最新进展

卷 26, 期 28, 2019

页: [5340 - 5362] 页: 23

弟呕挨: 10.2174/0929867325666180719144850

价格: $65

摘要

作为长期影响中老年人的中枢神经系统退行性疾病，帕金森氏病对我们不断增长的人口健康构成了日益严重的威胁。尽管我们对这种疾病的了解取得了显着进展，但目前所有可用的治疗方法仅可改善症状，但不能阻止疾病的进展。因此，必须开发，验证和使用更有效的药物发现方法和方法来发现帕金森氏病的缓解疾病的疗法。药物重新利用（也称为药物重新定位）或寻找现有或废弃药物的新用途的过程已被认为是开发新药物的经济高效且省时的方法，在药物研发领域与从头发现同样有希望神经变性，尤其是帕金森氏病。几个已建立的临床药物库的可用性以及疾病生物学，基因组学和生物信息学的快速发展刺激了计算机模拟和基于活动的药物重用的势头。随着临床上成功引入几种针对帕金森氏病的改用药物，药物再利用现已成为发现和开发该疾病新药的强有力的替代方法。在这篇评论中，将讨论针对帕金森氏病的药物替代疗法的最新进展。

关键词: 再利用药物，帕金森氏病，神经退行性疾病，多巴胺，α-突触核蛋白，神经炎症，神经保护。

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