Statins Therapy is Associated with Increased Populations of Early Endothelial Progenitor (CD133+/VEGFR2+) and Endothelial (CD34-/CD133- /VEGFR2+) Cells in Patients with Acute Ischemic Stroke

Title:Statins Therapy is Associated with Increased Populations of Early Endothelial Progenitor (CD133+/VEGFR2+) and Endothelial (CD34-/CD133- /VEGFR2+) Cells in Patients with Acute Ischemic Stroke

Volume: 15 Issue: 2

Author(s): Monika Golab-Janowska*, Edyta Paczkowska, Boguslaw Machalinski, Agnieszka Meller, Dariusz Kotlega, Krzysztof Safranow, Pawel Wankowicz and Przemyslaw Nowacki

Affiliation:

• Department of Neurology, Pomeranian Medical University, Szczecin,Poland

Keywords: Acute ischemic stroke, circulating stem cells (CD133+), early endothelial progenitor cells (CD133+/VEGFR2+), endothelial cells (CD34/CD133/VEGFR2+), statins, angiogenesis.

Abstract: Background: Endothelial Progenitor Cells (EPCs) have been suggested to be a therapeutic option in Acute Ischemic Stroke (AIS). Statins modulate endothelial function and preserve blood flow to tissue exposed to an ischemic insult. We tested the hypothesis that statins therapy might augment circulating EPCs in patients with AIS.

Methods: Demographic data, classical vascular risk factors, treatment and National Institutes of Health Stroke Scale data were prospectively collected from 43 consecutive AIS patients (group I), comprising – 30 treated with statins (group Statin(+)) and 13 untreated (group Statin (-)). Risk factor controls (group II) included 22 subjects matched by age, gender, and traditional vascular risk factors. EPCs were measured by flow cytometry – and the populations of circulating stem cells (CD133+), early EPCs (CD133+/VEGFR2+) and ECs CD34/CD133/VEGFR2+ cells were analyzed.

Results: Patients ages ranged from 54 to 92 years (mean age 75.2 ± 11.3 years). The number of CD34/CD133/VEGF-R2+ cells was significantly lower in group I than II (p<0.05). In group Statin(+) neurological deficit on the 1st, 3rd and 7th day was significantly lower in comparison Statin(-) (p<0.05). We observed significantly more frequent “improvement> 50% or complete recovery” and less frequent death in the statin-treated group. The number of early EPCs and ECs was significantly higher in the treated group on the day 3rd (p < 0.05).

Conclusions: Statins treatment is likely to have a positive effect on spontaneous CD133+/ VEGFR2+ and CD34/CD133/VEGFR2+ cell mobilization triggered by a stroke.

Cite this article as:

Golab-Janowska Monika *, Paczkowska Edyta , Machalinski Boguslaw , Meller Agnieszka , Kotlega Dariusz , Safranow Krzysztof , Wankowicz Pawel and Nowacki Przemyslaw , Statins Therapy is Associated with Increased Populations of Early Endothelial Progenitor (CD133+/VEGFR2+) and Endothelial (CD34-/CD133- /VEGFR2+) Cells in Patients with Acute Ischemic Stroke, Current Neurovascular Research 2018; 15 (2) . https://dx.doi.org/10.2174/1567202615666180611120546