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Cardiovascular & Hematological Disorders-Drug Targets

Editor-in-Chief

ISSN (Print): 1871-529X
ISSN (Online): 2212-4063

Citrus Flavonoids and the Prevention of Atherosclerosis

Author(s): Erin E. Mulvihill and Murray W. Huff

Volume 12, Issue 2, 2012

Page: [84 - 91] Pages: 8

DOI: 10.2174/1871529X11202020084

Price: $65

Abstract

Epidemiological studies have demonstrated that diets rich in fruits and vegetables can prevent or delay the onset of many chronic diseases including cardiovascular disease (CVD). While more current research has begun to focus on the effects of specific polyphenol compounds found in fruits and vegetables, mechanistic insights have been hampered by the multiple simultaneous effects these compounds may have on the disease process. In this article, we review the basic research studies that have evaluated the effects of citrus flavonoids to: improve dyslipidemia, normalize glucose homeostasis, prevent oxidative stress, and attenuate inflammation, which collectively have the ability to enhance metabolic health and improve CVD risk.

Keywords: ApoB, atherosclerosis, cardiovascular disease, flavonoids, hesperitin, insulin resistance, naringenin, nobiletin, tangeretin


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