Cyclophilin A: A Predictive Biomarker of Carotid Stenosis in Cerebral Ischemic Stroke

Title:Cyclophilin A: A Predictive Biomarker of Carotid Stenosis in Cerebral Ischemic Stroke

Volume: 15 Issue: 2

Author(s): Chen-Shu Chang, Shih-Li Su, Chen-Ling Kuo, Ching-Shan Huang, Wan-Min Tseng, Song-Shei Lin*Chin-San Liu*

Affiliation:

• Department of Medical Imaging and Radiological Sciences, Central-Taiwan University of Science and Technology, Taichung 406,Taiwan

• Vascular and Genomic Research Center, Changhua Christian Hospital, Changhua 500,Taiwan

Keywords: Cyclophilin A, ischemic stroke, inflammation, atherosclerosis, reactive oxygen species, carotid intima-media thickness.

Abstract: Background: Cyclophilin A plays a pathogenic role in the development and progression of atherosclerosis, which can be assessed by measuring carotid intima-media thickness. The primary aim of this study was to examine the interaction between plasma Cyclophilin A level and carotid intima-media thickness in patients with acute ischemic stroke.

Method: Plasma concentration of Cyclophilin A was measured on admission in 66 consecutive patients who had been hospitalized for acute cerebral stroke and in 52 case-control subjects without a history of acute stroke. Subjects in both groups also underwent ultrasound B-mode imaging to measure the mean and maximum intima-media thickness of the carotid artery. Inflammatory biomarkers including high-sensitivity C-reactive protein and fibrinogen were also assessed.

Results: We found that the plasma concentration of Cyclophilin A was significantly higher in patients with acute ischemic stroke (p = 0.042). Increased Cyclophilin A was also correlated with carotid intima-media thickness in the patient group (p < 0.001). Among the risk factors for cerebral stroke examined in this study, only hypertension was significantly associated with plasma Cyclophilin A level.

Conclusion: Increased plasma Cyclophilin A levels might be involved in the pathophysiology of acute ischemic stroke and Cyclophilin A might serve as a biomarker in risk assessment of acute stroke patients.

Cite this article as:

Chang Chen-Shu , Su Shih-Li, Kuo Chen-Ling , Huang Ching-Shan , Tseng Wan-Min , Lin Song-Shei *, Liu Chin-San *, Cyclophilin A: A Predictive Biomarker of Carotid Stenosis in Cerebral Ischemic Stroke, Current Neurovascular Research 2018; 15 (2) . https://dx.doi.org/10.2174/1567202615666180516120959