MicroRNA-155 Regulates Inflammatory Response in Ischemic Cerebral Tissues through Autophagy

Title:MicroRNA-155 Regulates Inflammatory Response in Ischemic Cerebral Tissues through Autophagy

Volume: 15 Issue: 2

Author(s): Yi Yang, Ning Zhang, Shan Wang and Ya Wen*

Affiliation:

• Department of Neurology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory for Neurology, Hebei, 050000,China

Keywords: miR-155, autophagy, inflammatory response, ischemic cerebral tissues, ischemic stroke, hypoxic damages.

Abstract: Our previous work has indicated that miR-155 expression induces inflammatory responses in ischemic cerebral tissues. However, the delicate regulation of miR-155-modifed inflammatory responses has remained enigmatic. In the present study, we found that autophagy is induced by ischemia through miR-155 and involved in neural injury. Subsequently, miR-155- induced autophagy modifies inflammatory responses through regulating TLR4/NF-κB pathway in ischemic cerebral tissues. Thus, miR-155 elevated autophagy is detrimental for ischemic cerebral injury and miR-155-induced autophagy modulates inflammatory responses through activating TLR4/NF-κB pathway.

Cite this article as:

Yang Yi , Zhang Ning , Wang Shan and Wen Ya *, MicroRNA-155 Regulates Inflammatory Response in Ischemic Cerebral Tissues through Autophagy, Current Neurovascular Research 2018; 15 (2) . https://dx.doi.org/10.2174/1567202615666180601081409