Chitosan-coated C-phycocyanin Liposome for Extending the Neuroprotective Time Window Against Ischemic Brain Stroke

Title:Chitosan-coated C-phycocyanin Liposome for Extending the Neuroprotective Time Window Against Ischemic Brain Stroke

Volume: 24 Issue: 17

Author(s): Goo Yong Chung, Kyou Hee Shim, Hye Jin Kim, Seul Ki Min and Hwa Sung Shin*

Affiliation:

• Department of Biological Engineering, Inha University, Incheon, 22212,Korea

Keywords: Chitosan, C-phycocyanin, neuroprotection, liposome, ischemia and reperfusion, brain stroke.

Abstract: The time window for neuroprotection during ischemic brain stroke is short, and hence, development of neuroprotectants is critical to extend this time window. This study sought to verify if muco-adhesive chitosan coating improves the neuroprotective potential of the pre-proven C-Phycocyanin-pertaining liposome (C-Pc liposome). The use of chitosan-coated liposomes extended the neuroprotective time window by 6 h after occlusion, and further improved the neuroprotection efficiency of the C-Pc liposome in a rat Middle Cerebral Artery Occlusion (MCAO) model. Beneficial changes in mRNA expressions of antioxidants, inflammatory cytokines and glia scar proteoglycans were evident in the C-Pc liposomes. In addition, in the cultured astrocytes, the chitosan- coated C-Pc liposome expressed anti-oxidative activity without cytotoxicity.

Cite this article as:

Chung Yong Goo , Shim Hee Kyou , Kim Jin Hye , Min Ki Seul and Shin Sung Hwa *, Chitosan-coated C-phycocyanin Liposome for Extending the Neuroprotective Time Window Against Ischemic Brain Stroke, Current Pharmaceutical Design 2018; 24 (17) . https://dx.doi.org/10.2174/1381612824666180515123543