摘要
ATP结合盒（ABC）转运蛋白是在分泌性上皮细胞如肝，肾和肠中表达的跨膜蛋白，在表现出屏障功能的上皮细胞如血脑屏障和胎盘中，并且在较小程度上在生殖器官等组织中表达。 ，肺，心脏和胰腺等。它们调节内源性代谢物和异生素的内部分布，包括治疗用药物，并参与从体内消除。我们在这里描述ABC转运蛋白在心脏和小肠中的功能和调节，作为肝外组织的例子，其中ABC蛋白发挥明显不同的作用。在心脏中，它们参与组织发病机制以及保护该器官免受有毒化合物和药物诱导的氧化应激的影响。小肠高度暴露于口服治疗药物，因此，位于其表面的ABC转运蛋白强烈影响药物吸收和药代动力学。目前描述的ABC蛋白的实例分别是针对心脏和小肠的多药抗性相关蛋白1和2（MRP1和2），以及针对两种器官的P-糖蛋白（P-gp）和乳腺癌抗性蛋白（BCRP）。
关键词: ATP结合盒转运蛋白，P-糖蛋白，多药耐药相关蛋白，乳腺癌耐药蛋白，心脏，肠，药物转运。
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[http://dx.doi.org/10.1002/jbt.21880]
[http://dx.doi.org/10.1002/jbt.21880]
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