Mechanism and Inhibition of Matrix Metalloproteinases

doi:10.2174/0929867325666180326163523
摘要

基质金属蛋白酶水解蛋白质和糖蛋白，形成细胞外基质，细胞外空间释放的细胞因子和生长因子，以及外细胞膜上的膜结合受体。 MMP的病理相关性促使这些酶的结构和功能表征以及合成抑制剂作为可能的候选药物的开发。最近的研究提供了对家族不同成员的底物偏好的更好理解，以及这些酶水解底物的机制的结构数据。在这里，我们报告了胶原蛋白溶解和弹性溶解机制的最新进展，并讨论了靶向MMP的新治疗策略的前景。
关键词: 基质金属蛋白酶，酶，机制，胶原溶解，弹性溶解，抑制剂。
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DOI https://dx.doi.org/10.2174/0929867325666180326163523	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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