黄酮类化合物治疗阿尔茨海默氏症及其他神经退行性疾病

Title:Flavonoids in the Treatment of Alzheimer’s and Other Neurodegenerative Diseases

Volume: 25 Issue: 27

关键词: 阿尔茨海默病、类黄酮、神经退行性疾病、抗氧化剂、合成方法、类似物。

摘要: Flavonoids are phytochemicals present in almost all terrestrial plants and, as a consequence, in plant-based foods, and thus consumed by humans through diet. Recent evidences suggest that several flavonoids have positive effects against dementia and Alzheimer’s disease, reversing age-related declines in neurocognitive performances. In this review, we provide a general classification of natural and synthetic flavonoids, a description of their physico-chemical properties, in particular their redox properties and stability, and an extensive overview about their biological activities and structure-activity relationship in the field of neurodegenerative diseases. In addition, a section will be dedicated to the synthetic strategies for the preparation of bioactive derivatives. This information will be essential for the design and development of new drugs that can improve brain functions.

Cite this article as:

Flavonoids in the Treatment of Alzheimer’s and Other Neurodegenerative Diseases, Current Medicinal Chemistry 2018; 25 (27) . https://dx.doi.org/10.2174/0929867325666180209132125