Abstract
Magnetic resonance imaging (MRI) of the human brain plays an important role in the field of medical imaging as well as basic neuroscience. It measures proton spin relaxation, the time constant of which depends on tissue type, and allows us to visualize anatomical structures in the brain. It can also measure functional signals that depend on the local ratio of oxyhemoglobin to deoxyhemoglobin in the blood, which is believed to reflect the degree of neural activity in the corresponding area. MRI thus provides anatomical and functional information about the human brain with high spatial resolution. Conventionally, MRI signals are measured and analyzed for each individual voxel. However, these signals are essentially multivariate because they are measured from multiple voxels simultaneously, and the pattern of activity might carry more useful information than each individual voxel does. This paper reviews recent trends in multivariate analysis of MRI signals in the human brain, and discusses applications of this technique in the fields of medical imaging and neuroscience.
Keywords: Magnetic resonance imaging, Medical imaging, Neuroscience, Machine learning, Pattern classification, Diagnosis, perception, Vision.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Multivariate Analysis of Magnetic Resonance Imaging Signals of the Human Brain
Volume: 16 Issue: 24
Author(s): Yoichi Miyawaki
Affiliation:
Keywords: Magnetic resonance imaging, Medical imaging, Neuroscience, Machine learning, Pattern classification, Diagnosis, perception, Vision.
Abstract: Magnetic resonance imaging (MRI) of the human brain plays an important role in the field of medical imaging as well as basic neuroscience. It measures proton spin relaxation, the time constant of which depends on tissue type, and allows us to visualize anatomical structures in the brain. It can also measure functional signals that depend on the local ratio of oxyhemoglobin to deoxyhemoglobin in the blood, which is believed to reflect the degree of neural activity in the corresponding area. MRI thus provides anatomical and functional information about the human brain with high spatial resolution. Conventionally, MRI signals are measured and analyzed for each individual voxel. However, these signals are essentially multivariate because they are measured from multiple voxels simultaneously, and the pattern of activity might carry more useful information than each individual voxel does. This paper reviews recent trends in multivariate analysis of MRI signals in the human brain, and discusses applications of this technique in the fields of medical imaging and neuroscience.
Export Options
About this article
Cite this article as:
Miyawaki Yoichi, Multivariate Analysis of Magnetic Resonance Imaging Signals of the Human Brain, Current Topics in Medicinal Chemistry 2016; 16 (24) . https://dx.doi.org/10.2174/1568026616666160413135303
DOI https://dx.doi.org/10.2174/1568026616666160413135303 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Medicinal Chemistry Advancement in Life-Threatening Diseases
The current issue will highlight concise reports that specify ground-breaking insights, including the novel discovery of drug targets and their action mechanism or drugs of novel classes. These are projected to encourage medicinal chemistry future efforts to address the most challenging medical needs. The current issue highlights further efforts to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy
Current Pharmaceutical Design Targeted Anti-leukemic Therapy as Disease-stabilizing Treatment for Acute Myeloid Leukemia Relapse after Allogeneic Stem Cell Transplantation: Will it be Possible to Combine these Strategies with Retransplantation or Donor Lymphocyte Infusions?
Current Cancer Drug Targets Stopping Drug Therapy in Epilepsy
Current Pharmaceutical Design Analyses of Associations Between Reactive Oxygen Metabolites and Antioxidant Capacity and Related Factors Among Healthy Adolescents
Current Aging Science Expanding Spectrum of Sodium Potassium Chloride Co-transporters in the Pathophysiology of Diseases
Current Neuropharmacology Protein-Energy Malnutrition Alters Hippocampal Plasticity-Associated Protein Expression following Global Ischemia in the Gerbil
Current Neurovascular Research Neurotransmitters and Chemokines Regulate Tumor Cell Migration: Potential for a New Pharmacological Approach to Inhibit Invasion and Metastasis Development
Current Pharmaceutical Design Amyloid β Oligomers Decrease Hippocampal Spontaneous Network Activity in an Age-Dependent Manner
Current Alzheimer Research Neural Correlates in Patients with Major Affective Disorders: An fMRI Study
CNS & Neurological Disorders - Drug Targets Histone Post-translational Modifications in Huntington’s and Parkinson’s Diseases
Current Pharmaceutical Design Occurrence of DAT1 (VNTR) Polymorphism in Individuals with HIV Infection
Current Pharmacogenomics and Personalized Medicine Association and Causal Relationship of Midlife Obesity and Related Metabolic Disorders with Old Age Cognition
Current Alzheimer Research The Muscular Dystrophies Associated with Central Nervous System Lesions: A Brief Review from a Standpoint of the Localization and Function of Causative Genes
Current Pediatric Reviews MicroRNAs in CAG Trinucleotide Repeat Expansion Disorders: an Integrated Review of the Literature
CNS & Neurological Disorders - Drug Targets Neurological Aspects of Medical Use of Cannabidiol
CNS & Neurological Disorders - Drug Targets PET Studies on P-Glycoprotein Function in the Blood-Brain Barrier: How it Affects Uptake and Binding of Drugs within the CNS
Current Pharmaceutical Design Local Cerebral Blood Flow is Preserved in Sepsis
Current Neurovascular Research Neuroprotection Against Ischemic / Hypoxic Brain Damage: Blockers of Ionotropic Glutamate Receptor and Voltage Sensitive Calcium Channels
Current Drug Targets Piroxicam: Source for Synthesis of Central Nervous System (CNS) Acting Drugs
Central Nervous System Agents in Medicinal Chemistry CNS Transporters and Drug Delivery in Epilepsy
Current Pharmaceutical Design