摘要
本文回顾了免疫调节或免疫治疗在转移性乳腺癌中的主要尝试。它考虑了它们的基本原理并报告了相关关键临床试验的结果。单独使用或与常规疗法组合使用的免疫调节或免疫刺激细胞因子是乳腺癌免疫操作的主要方法之一。由于我们最近对此问题进行了审核，因此本文的目的是讨论有关此主题的更新和未发布的数据。管腔（28例）和非腔（9例）分子亚型的总存活率分别为91和59个月，比预期长约2.5倍或3倍。此后，我们专注于基于单克隆抗体（mAb）的治疗，包括克服抗HER2mAb抗性的新策略。最后一节讨论了不同分子亚型的主要疫苗平台和三阴性转移性乳腺癌（m-TNBC）的免疫治疗。一些III期调查已经改变了目前的临床实践。事实上，帕妥珠单抗加曲妥珠单抗和多西紫杉醇是HER2阳性局部复发或转移性乳腺癌的推荐一线方案，贝伐单抗加紫杉醇或多西紫杉醇是m-TNBC的合理选择。在一线曲妥珠单抗加化疗和激素治疗的一些其他观察或阶段I / II研究中以及在HER2肽/蛋白质疫苗上的研究，虽然已经报道了初步研究结果有待进一步验证。在其余的研究中，结果令人失望。将来，寻找新的预测性生物标志物并探索更合适的协同组合，当前和进一步研究的免疫学方法的时间和剂量依赖性预定序列是主要挑战。
关键词: 免疫疗法，乳腺癌，细胞因子，mAb，m-TNBC，干扰素。
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