Review Article

胶原蛋白和胶原蛋白材料的医学应用

卷 26, 期 3, 2019

页: [506 - 516] 页: 11

弟呕挨: 10.2174/0929867325666171205170339

价格: $65

摘要

胶原蛋白和胶原蛋白材料已成功应用于医学领域超过50年。近年来,关于胶原蛋白在组织工程支架构建中的作用的科学论文数量急剧增加。该综述包含关于胶原蛋白在医学中的历史和现代应用的材料,例如可溶性胶原蛋白注射,从溶液重建的固体构建体和脱细胞胶原基质。对已公布数据的分析证明了胶原材料在治疗慢性伤口,烧伤,静脉和糖尿病溃疡,塑料,重建和普通外科,泌尿科,直肠科,妇科,眼科,耳鼻喉科,神经外科,牙科,心血管和骨骼中的功效。和软骨外科,以及美容。胶原成形术的进一步发展需要解决过敏性并发症的问题,结构的改善和对病理过程的最大化治疗效果。

关键词: 胶原蛋白,天然聚合物,重建胶原蛋白,脱细胞胶原基质,支架,组织工程。

[1]
Mienaltowski, M.J.; Birk, D.E. Structure, physiology, and biochemistry of collagens. Adv. Exp. Med. Biol., 2014, 802, 5-29.
[2]
Gordon, M.K.; Hahn, R.A. Collagens. Cell Tissue Res., 2010, 339(1), 247-257.
[3]
Shoulders, M.D.; Raines, R.T. Collagen structure and stability. Annu. Rev. Biochem., 2009, 78, 929-958.
[4]
Trelstad, R.L. Human aorta collagens: Evidence for three distinct species. Biochem. Biophys. Res. Commun., 1974, 57(3), 717-725.
[5]
Pappas, A.M.; Hyatt, G.W. The evaluation of collagen film applied to skin defects in mice. Surg. Forum, 1960, 10, 844-846.
[6]
McBride, C.M.; Healey, J.E., Jr; Butler, J.J.; White, E.C. Use collagen cloth for repair of tissue defects. Surg. Forum, 1964, 15, 70-71.
[7]
Abbenhaus, J.I.; Donald, P. The use of collagen grafts for replacement of major skin loss. Laryngoscope, 1971, 81(10), 1650-1651.
[8]
Wanke, M.; Collins, R.L.; Hartmann, R.; Linder, M.M.; Sebening, H. [Structure dependent wound healing with temporary skin substitute of collagen foam film] Frankf. Z. Pathol., 1967, 77(2), 125-134.
[9]
Friderich, H.G.; Vakilzadeh, F.; Goebel, M. Study of wound healing with animal collagen films. Z. Haut. U. Geschl. Kr., 1968, 5, 325-334.
[10]
Morgenstern, L. Experimental partial splenectomy: application of cyanoacrylate monomer tissue adhesive for hemostasis. Am. Surg., 1965, 31(11), 709-712.
[11]
Peacock, E.E., Jr; Seigler, H.F.; Biggers, P.W. Use of tanned col-lagen sponges in the treatment of liver injuries. Ann. Surg., 1965, 161, 238-247.
[12]
Preobrazhensky, N.; Goldman, I.I.; Aboyants, R.K.; Ruden-ko, T.G. Application of collagen in reconstruction of auris media. News Otolaryngol., 1973, 6, 57-62.
[13]
Dronov, A.F.; Rudenko, T.G.; Arutunova, V.A. Collagen-minomycin complex. Antibiotics (Basel), 1977, 3, 283-286.
[14]
Rudenko, T.G.; Dronov, A.F.; Geraskin, V.I.; Shtihno, O.F. Experimental application of collagen-minomycin sponge Clin. Aspects Surg. Anat. Exp. Surgery, 1979. 137-141
[15]
Segalova, N.E.; Dubinskaya, A.M.; Istranov, L.P.; Aboyants, R.K.; Nikitina, L.A.; Rudenko, T.G. Preparation and properties of composites of collagen with terrilitin. Pharm. Chem. J., 1988, 22(6), 491-495.
[16]
Istranov, L.P.; Aboyants, R.K.; Belozerskaya, G.G.; Istrano-va, E.V.; Makarov, V.A. Local hemostatic collagen materials. Pharmacy (Basel), 2007, 7, 29-32.
[17]
Vaza, A.U.; Shekhter, A.B.; Istranov, L.P.; Kanakov, I.V. Experimental development of method for stimulated healing of bone-cartilage defects. . Healthcare and medical technologies, 2008, 1 8-12
[18]
Ermolova, A.S.; Smirnova, S.V.; Hvatov, V.B.; Istranov, L.P.; Mironov, L.L.; Kolokolchikova, E.G.; Sichevsky, M.V.; Bocharova, V.S. Biological dressing for III degree burn wounds. Surgery, 2008, 10, 4-9.
[19]
Istranova, E.V.; Aboyants, R.K.; Istranov, L.P. Antimicrobal activity of collagen sponges. Pharmacy (Basel), 2011, 1, 34-37.
[20]
Istranova, E.V.; Istranov, L.P.; Aboyants, R.K.; Chertova, E.N. Ichtiol – new collagen substance. PharmacyI., 2004, 5, 34-37.
[21]
Aboyants, R.K.; Istranov, L.P.; Shekhter, A.B. Gapcol – new osteoplastic material, 1997. 5
[22]
Levchik, E.U.; Aboyants, R.K.; Istranov, L.P.; Rudenko, T.G. External protection of the intestine anastomoses by col-lagen explants. Immunol. Lett., 1997, 56(2), 490.
[23]
Shekhter, A.B.; Rudenko, T.G.; Istranov, L.P.; Guller, A.E.; Borodulin, R.R.; Vanin, A.F. Dinitrosyl iron complexes with glutathione incorporated into a collagen matrix as a base for the design of drugs accelerating skin wound healing. Eur. J. Pharm. Sci., 2015, 78, 8-18.
[24]
Shekhter, A.B.; Guller, A.E.; Istranov, L.P.; Istranova, E.V.; Butnaru, D.V.; Vinarov, A.Z.; Zakharkina, O.L.; Kurkov, A.V.; Kantimerov, D.F.; Antonov, E.N.; Marisov, L.V.; Glybochko, P.V. [Morphology of collagen matrices for tissue engineering (biocompatibility, biodegradation, tissue response)]. Arkh. Patol., 2015, 77(6), 29-38.
[25]
Shekhter, A.B. Connective tissue as an integral system: role of cell-cell and cell-matrix interactions. Connect. Tissue Res., 1986, 15(1-2), 23-31.
[26]
Lucey, P.; Goldberg, D.J. Complications of collagen fillers. Facial Plast. Surg., 2014, 30(6), 615-622.
[27]
Parenteau-Bareil, R.; Gauvin, R.; Berthod, F. Collagen-based biomaterials for tissue engineering applications. Materials (Basel), 2010, 3(3), 1863-1887.
[28]
Motta, G.; Ratto, G.B.; De Barbieri, A.; Corte, G.; Zardi, L.; Sacco, A.; Castagnola, M. Can heterologous collagen enhance the granulation tissue growth? An experimental study. Ital. J. Surg. Sci., 1983, 13(2), 101-108.
[29]
Singh, O.; Gupta, S.S.; Soni, M.; Moses, S.; Shukla, S.; Mathur, R.K. Collagen dressing versus conventional dressings in burn and chronic wounds: a retrospective study. J. Cutan. Aesthet. Surg., 2011, 4(1), 12-16.
[30]
Veves, A.; Sheehan, P.; Pham, H.T.A. A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers. Arch. Surg., 2002, 137(7), 822-827.
[31]
Lou, R.B.; Hickerson, W.L. The use of skin substitutes in hand burns. Hand Clin., 2009, 25(4), 497-509.
[32]
Landsman, A.; Taft, D.; Riemer, K. The role of collagen bioscaffolds, foamed collagen, and living skin equivalents in wound healing. Clin. Podiatr. Med. Surg., 2009, 26(4), 525-533.
[33]
Landsman, A.S.; Cook, J.; Cook, E.; Landsman, A.R.; Garrett, P.; Yoon, J.; Kirkwood, A.; Desman, E. A retrospective clinical study of 188 consecutive patients to examine the effectiveness of a biologically active cryopreserved human skin allograft (Theraskin®) on the treatment of diabetic foot ulcers and venous leg ulcers. Foot Ankle Spec., 2011, 4(1), 29-41.
[34]
Ermolov, A.S.; Smirnov, S.V.; Khvatov, V.B.; Istranov, L.P.; Koniushko, O.I.; Kolokolchikova, E.G.; Sychevsky, M.V.; Bocharova, V.S. The use of bioactive wound dressing, stimulating epithelial regeneration of IIIa-degree burn wounds. Bull. Exp. Biol. Med., 2008, 146(1), 153-157.
[35]
Corcos, J.; Collet, J.P.; Shapiro, S.; Herschorn, S.; Radomski, S.B.; Schick, E.; Gajewski, J.B.; Benedetti, A.; MacRamallah, E.; Hyams, B. Multicenter randomized clinical trial comparing surgery and collagen injections for treatment of female stress urinary incontinence. Urology, 2005, 65(5), 898-904.
[36]
Davis, N.F.; Kheradmand, F.; Creagh, T. Injectable biomaterials for the treatment of stress urinary incontinence: Their potential and pitfalls as urethral bulking agents. Int. Urogynecol. J. Pelvic Floor Dysfunct., 2013, 24(6), 913-919.
[37]
Läckgren, G.; Wåhlin, N.; Stenberg, A. Endoscopic treatment of children with vesico-ureteric reflux. Acta Paediatr. Suppl., 1999, 88(431), 62-71.
[38]
Maeda, Y.; Laurberg, S.; Norton, C.S. Perianal injectable bulking agents as treatment for faecal incontinence. Cochrane Database Syst. Rev., 2009, 15(3), CD007956.
[39]
King, J.M.; Simpson, C.B. Modern injection augmentation for glottic insufficiency. Curr. Opin. Otolaryngol. Head Neck Surg., 2007, 15(3), 153-158.
[40]
Kościński, T.; Szubert, S.; Sajdak, S. Advantages of implantation of acellular porcine-derived mesh in the treatment of human rectocele - Case report. Ann. Agric. Environ. Med., 2016, 23(4), 692-695.
[41]
Slater, N.J.; van der Kolk, M.; Hendriks, T.; van Goor, H.; Bleichrodt, R.P. Biologic grafts for ventral hernia repair: A systematic review. Am. J. Surg., 2013, 205(2), 220-230.
[42]
Kissane, N.A.; Itani, K.M.F. A decade of ventral incisional hernia repairs with biologic acellular dermal matrix. Plast. Reconstr. Surg., 2012, 130(5)(Suppl. 2), 194S-202S.
[43]
Ibrahim, A.M.S.; Ayeni, O.A.; Hughes, K.B.; Lee, B.T.; Slavin, S.A.; Lin, S.J. Acellular dermal matrices in breast surgery: A comprehensive review. Ann. Plast. Surg., 2013, 70(6), 732-738.
[44]
Atala, A. Regenerative medicine strategies. J. Pediatr. Surg., 2012, 47(1), 17-28.
[45]
Akbal, C.; Lee, S.D.; Packer, S.C.; Davis, M.M.; Rink, R.C.; Kaefer, M. Bladder augmentation with acellular dermal biomatrix in a diseased animal model. J. Urol., 2006, 176(4 Pt 2)(Suppl.), 1706-1711.
[46]
Lin, J.; Hao, J.R.; Jin, J.; Deng, S.M.; Hu, J.; Na, Y.Q. [Homologous dermal acellular matrix graft for urethral reconstruction in man (report of 16 cases)]. Zhonghua Yi Xue Za Zhi, 2005, 85(15), 1057-1059.
[47]
Atala, A.; Bauer, S.B.; Soker, S.; Yoo, J.J.; Retik, A.B. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet, 2006, 367(9518), 1241-1246.
[48]
Raya-Rivera, A.M.; Esquiliano, D.; Fierro-Pastrana, R.; López-Bayghen, E.; Valencia, P.; Ordorica-Flores, R.; Soker, S.; Yoo, J.J.; Atala, A. Tissue-engineered autologous vaginal organs in patients: A pilot cohort study. Lancet, 2014, 384(9940), 329-336.
[49]
Hamilton, N.J.; Kanani, M.; Roebuck, D.J.; Hewitt, R.J.; Cetto, R.; Culme-Seymour, E.J.; Toll, E.; Bates, A.J.; Comerford, A.P.; McLaren, C.A.; Butler, C.R.; Crowley, C.; McIntyre, D.; Sebire, N.J.; Janes, S.M.; O’Callaghan, C.; Mason, C.; De Coppi, P.; Lowdell, M.W.; Elliott, M.J.; Birchall, M.A. Tissue-engineered tracheal replacement in a child: A 4-year follow-up study. Am. J. Transplant., 2015, 15(10), 2750-2757.
[50]
Erdogan, D.; van Gulik, T.M. Evolution of fibrinogen-coated collagen patch for use as a topical hemostatic agent. J. Biomed. Mater. Res. B Appl. Biomater., 2008, 85(1), 272-278.
[51]
Fleischer, D. Endoscopic therapy of upper gastrointestinal bleeding in humans. Gastroenterology, 1986, 90(1), 217-234.
[52]
Chang, W.K.; Srinivasa, S.; MacCormick, A.D.; Hill, A.G. Gentamicin-collagen implants to reduce surgical site infection. Ann. Surg., 2013, 258(1), 59-65.
[53]
Creanor, S.; Barton, A.; Marchbank, A. Effectiveness of a gentamicin impregnated collagen sponge on reducing sternal wound infections following cardiac surgery: a meta-analysis of randomised controlled trials. Ann. R. Coll. Surg. Engl., 2012, 94(4), 227-231.
[54]
Hussain, S.T. Local application of gentamicin-containing collagen implant in the prophylaxis and treatment of surgical site infection following vascular surgery. Int. J. Surg., 2012, 10(Suppl. 1), S5-S9.
[55]
de Bruin, A.F.J.; Gosselink, M.P.; van der Harst, E. Local application of gentamicin-containing collagen implant in the prophylaxis of surgical site infection following gastrointestinal surgery. Int. J. Surg., 2012, 10(Suppl. 1), S21-S27.
[56]
Knaepler, H. Local application of gentamicin-containing collagen implant in the prophylaxis and treatment of surgical site infection in orthopaedic surgery. Int. J. Surg., 2012, 10(Suppl. 1), S15-S20.
[57]
Grigoryants, V.; Jane, J.A., Jr; Lin, K.Y. Salvage of a complicated myelomeningocele using collagen (Duragen) and dermal (Alloderm) matrix substitutes. Case report and review of the literature. Pediatr. Neurosurg., 2007, 43(6), 512-515.
[58]
Deal, D.N.; Griffin, J.W.; Hogan, M.V. Nerve conduits for nerve repair or reconstruction. J. Am. Acad. Orthop. Surg., 2012, 20(2), 63-68.
[59]
Khaing, Z.Z.; Schmidt, C.E. Advances in natural biomaterials for nerve tissue repair. Neurosci. Lett., 2012, 519(2), 103-114.
[60]
Pabari, A.; Yang, S.Y.; Mosahebi, A.; Seifalian, A.M. Recent advances in artificial nerve conduit design: Strategies for the delivery of luminal fillers. J. Control. Release, 2011, 156(1), 2-10.
[61]
Han, S.; Wang, B.; Jin, W.; Xiao, Z.; Li, X.; Ding, W.; Kapur, M.; Chen, B.; Yuan, B.; Zhu, T.; Wang, H.; Wang, J.; Dong, Q.; Liang, W.; Dai, J. The linear-ordered collagen scaffold-BDNF complex significantly promotes functional recovery after completely transected spinal cord injury in canine. Biomaterials, 2015, 41, 89-96.
[62]
Fagerholm, P.; Lagali, N.S.; Ong, J.A.; Merrett, K.; Jackson, W.B.; Polarek, J.W.; Suuronen, E.J.; Liu, Y.; Brunette, I.; Griffith, M. Stable corneal regeneration four years after implantation of a cell-free recombinant human collagen scaffold. Biomaterials, 2014, 35(8), 2420-2427.
[63]
Sultana, Y.; Jain, R.; Aqil, M.; Ali, A. Review of ocular drug delivery. Curr. Drug Deliv., 2006, 3(2), 207-217.
[64]
Cillino, S.; Di Pace, F.; Cillino, G.; Casuccio, A. Biodegradable collagen matrix implant vs mitomycin-C as an adjuvant in trabeculectomy: A 24-month, randomized clinical trial. Eye (Lond.), 2011, 25(12), 1598-1606.
[65]
Hayek, B.; Hatef, E.; Nguyen, M.; Ho, V.; Hsu, A.; Esmaeli, B. Acellular dermal graft (AlloDerm) for upper eyelid reconstruction after cancer removal. Ophthal. Plast. Reconstr. Surg., 2009, 25(6), 426-429.
[66]
Peter, N.M.; Kumar, B. Permacol in eyelid reconstruction -- a novel use. Orbit, 2013, 32(1), 57-59.
[67]
Haynes, D.S.; Vos, J.D.; Labadie, R.F. Acellular allograft dermal matrix for tympanoplasty. Curr. Opin. Otolaryngol. Head Neck Surg., 2005, 13(5), 283-286.
[68]
Gryskiewicz, J.M. Waste not, want not: The use of AlloDerm in secondary rhinoplasty. Plast. Reconstr. Surg., 2005, 116(7), 1999-2004.
[69]
Gillogly, S.D.; Wheeler, K.S. Autologous chondrocyte implantation with collagen membrane. Sports Med. Arthrosc. Rev., 2015, 23(3), 118-124.
[70]
Grassi, A.; Zaffagnini, S.; Marcheggiani Muccioli, G.M.; Benzi, A.; Marcacci, M. Clinical outcomes and complications of a collagen meniscus implant: A systematic review. Int. Orthop., 2014, 38(9), 1945-1953.
[71]
Zaffagnini, S.; Grassi, A.; Marcheggiani Muccioli, G.M.; Bonanzinga, T.; Nitri, M.; Raggi, F.; Ravazzolo, G.; Marcacci, M. MRI evaluation of a collagen meniscus implant: A systematic review. Knee Surg. Sports Traumatol. Arthrosc., 2015, 23(11), 3228-3237.
[72]
Ferreira, A.M.; Gentile, P.; Chiono, V.; Ciardelli, G. Collagen for bone tissue regeneration. Acta Biomater., 2012, 8(9), 3191-3200.
[73]
Huang, Z.; Feng, Q.; Yu, B.; Li, S. Biomimetic properties of an injectable chitosan/nano-hydroxyapatite/ collagen composite. Mater. Sci. Eng. C, 2011, 31(3), 683-687.
[74]
Sotome, S.; Uemura, T.; Kikuchi, M.; Chen, J.; Itoh, S.; Tanaka, J.; Tateishi, T.; Shinomiya, K. Synthesis and in vivo evaluation of a novel hydroxyapatite/collagen–alginate as a bone filler and a drug delivery carrier of bone morphogenetic protein. Mater. Sci. Eng. C, 2004, 24(3), 341-347.
[75]
Van Vijven, J.P.J.; Luijsterburg, P.A.J.; Verhagen, A.P.; van Osch, G.J.V.M.; Kloppenburg, M.; Bierma-Zeinstra, S.M.A. Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: A systematic review. Osteoarthritis Cartilage, 2012, 20(8), 809-821.
[76]
Park, K.S.; Park, M.J.; Cho, M.L.; Kwok, S.K.; Ju, J.H.; Ko, H.J.; Park, S.H.; Kim, H.Y.; Type, I.I. Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis. Mod. Rheumatol., 2009, 19(6), 581-589.
[77]
Thoma, D.S.; Buranawat, B.; Hämmerle, C.H.F.; Held, U.; Jung, R.E. Efficacy of soft tissue augmentation around dental implants and in partially edentulous areas: a systematic review. J. Clin. Periodontol., 2014, 41(Suppl. 15), S77-S91.
[78]
Patino, M.G.; Neiders, M.E.; Andreana, S.; Noble, B.; Cohen, R.E. Collagen as an implantable material in medicine and dentistry. J. Oral Implantol., 2002, 28(5), 220-225.
[79]
Huang, A.H.; Niklason, L.E. Engineering of arteries in vitro. Cell. Mol. Life Sci., 2014, 71(11), 2103-2118.
[80]
Keuren, J.F.W.; Wielders, S.J.H.; Driessen, A.; Verhoeven, M.; Hendriks, M.; Lindhout, T. Covalently-bound heparin makes collagen thromboresistant. Arterioscler. Thromb. Vasc. Biol., 2004, 24(3), 613-617.
[81]
Sanz-Garcia, A.; Oliver-de-la-Cruz, J.; Mirabet, V.; Gandía, C.; Villagrasa, A.; Sodupe, E.; Escobedo-Lucea, C. Heart valve tissue engineering: How far is the bedside from the bench? Expert Rev. Mol. Med., 2015, 17, e16.
[82]
Hilkin, A.M.; Shekhter, A.B.; Istranov, L.P.; Lemenev, V.L. Collagen and its application in medicine., 1976.
[83]
Sichenikov, I.A.; Aboyants, R.K.; Dronov, A.F.; Istranov, L.P.; Nikolaev, A.V.; Shekhter, A.B. Collagenoplasty in medicine., 1978.
[84]
Serov, V.V.; Shekhter, A.B. Connective tissue (functional morphology and general pathology); Medicina , 1981.

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    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) limit 1
      14.23msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 309684047
      • 1: 309684047
      • 2: 309684047
      • 3: 309684047
      • 4: 309684047
      • 5: 309684047
      • 6: 309684047
      • 7: 309684047
      • 8: 309684047
      • 9: 309684047
      • 10: 309684047
      • 11: 309684047
      • 12: 309684047
      • 13: 309684047
      • 14: 309684047
      • 15: 309684047
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=87272
      700μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 25 limit 1
      800μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 25
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=25) and sj.journal_id!=25 group by `j`.`nid`) as `aggregate_table`
      1.41msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=25) and sj.journal_id!=25 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      1.24msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=25) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      3.48msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=25) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      2.91msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '87272'
      290μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 87272
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '87272'
      3msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 87272
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '87272' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      2.31msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 87272
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      310μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      710μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 25 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      45.44msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 25 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      70.59msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 25 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      32.74msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 87272 limit 1
      270μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 87272
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 87272 and content_type = 'article' order by status desc limit 1
      570μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid article_nid,a.title article_title,j.title journal_title from content_by_diseases cd inner join article a on a.article_id=cd.content_id inner join journal j on j.journal_id=a.journal_id where cd.pid = 258 and cd.sub_disease_id = 403 and content_id!=87272 and cd.content_type = 'article' order by rand() limit 20
      27.2msalphaeurekaselec_live_10_06_2022Article.php#769
      Backtrace
      • 11. app/Models/Article.php:769
      • 12. app/Http/Controllers/ArticleController.php:2098
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 158107 limit 1
      360μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 158107
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      340μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CMC' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      540μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CMC
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '87272' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      470μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '9005' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      430μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '2572' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      430μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739847140 and j.to_date >= 1739847140 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2572) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739847140 and j.to_date >= 1739847140 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2572) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739847140 and j.to_date >= 1739847140 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2572)
      11.51msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739847140 and j.to_date >= 1739847140 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 9005) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739847140 and j.to_date >= 1739847140 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 9005) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739847140 and j.to_date >= 1739847140 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 9005)
      910μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739847140 and j.to_date >= 1739847140 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 87272) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739847140 and j.to_date >= 1739847140 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 87272) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739847140 and j.to_date >= 1739847140 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 87272)
      850μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '506' and is_uploaded = 1 and issue_id = 9005 order by cast(first_page as SIGNED) desc limit 1
      730μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 506
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '516' and is_uploaded = 1 and issue_id = 9005 order by cast(first_page as SIGNED) asc limit 1
      640μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 516
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'cn'
      230μsalphaeurekaselec_live_10_06_2022ArticleController.php#2486
      Bindings
      • 0: cn
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2486
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 2
      290μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 2
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2487
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `multilanguage_article` where (`language_id` = 2 and `article_id` = 87272)
      8.52msalphaeurekaselec_live_10_06_2022ArticleController.php#2488
      Bindings
      • 0: 2
      • 1: 87272
      Backtrace
      • 15. app/Http/Controllers/ArticleController.php:2488
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `keyword` from `multilanguage_keywords` where (`language_id` = 2 and `article_id` = 87272)
      4.53msalphaeurekaselec_live_10_06_2022ArticleController.php#2489
      Bindings
      • 0: 2
      • 1: 87272
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2489
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT_WS(' ',au.last_name, ', ', ifnull(au.initials,''), ' ', au.first_name) as authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs , `au`.*, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `multilanguage_authors` as `au` left join `multilanguage_author_affiliation` as `af` on `au`.`id` = `af`.`author_id` where `au`.`article_id` = 87272 group by `au`.`id` order by `au`.`article_id` asc, `au`.`sequence` asc
      6.39msalphaeurekaselec_live_10_06_2022MultiLangAuthor.php#30
      Bindings
      • 0: 87272
      Backtrace
      • 13. app/Models/MultiLangAuthor.php:30
      • 14. app/Http/Controllers/ArticleController.php:2493
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `multilanguage_journal`.`title` from `multilanguage_journal` where `multilanguage_journal`.`journal_id` = 25 and `language_id` = 2
      450μsalphaeurekaselec_live_10_06_2022ArticleController.php#2495
      Bindings
      • 0: 25
      • 1: 2
      Backtrace
      • 13. app/Http/Controllers/ArticleController.php:2495
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `id` from `multilanguage_article` where `article_id` = 87272 limit 1
      2.35msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 87272
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 25 and `b`.`banner_from_date` <= 1739847140 and `b`.`banner_to_date` >= 1739847140 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.6msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 25
      • 3: 1739847140
      • 4: 1739847140
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 25 and `b`.`banner_from_date` <= 1739847140 and `b`.`banner_to_date` >= 1739847140 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.49msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 25
      • 3: 1739847140
      • 4: 1739847140
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='e67866f192d25574438bd1585636d5cf'
      250μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLangArticle
    2MultiLangArticle.php#?
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        CtyRwUhlMoT6VpTymDVQhlziVTUetfpswl5ZLzWQ
        uc_cart_id
        e67866f192d25574438bd1585636d5cf
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/87272/cn" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/87272/cn
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6Ik5NUVhEdnIwVThvQXV0cGcxSC9LMFE9PSIsInZhbHVlIjoidWFDS0J5ekhCOVBIWkNoUnNxVjVYSU4ybFFLVGNQZ2xVcXRkZnc3Q2JTbz0iLCJtYWMiOiJjNjBkMjEzMTdkNGY0Njk1YTc5OTVjYTFjODAwNjRhOGYzYTRjMmQ2ODQ5MDVmYWQ3NWJhOWIwOWI5NDE0NTQxIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6Ik5NUVhEdnIwVThvQXV0cGcxSC9LMFE9PSIsInZhbHVlIjoidWFDS0J5ekhCOVBIWkNoUnNxVjVYSU4ybFFLVGNQZ2xVcXRkZnc3Q2JTbz0iLCJtYWMiOiJjNjBkMjEzMTdkNGY0" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
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