Abstract
Collagen and collagen-based materials have been successfully used in medicine for over 50 years. The number of scientific articles about the role of collagen in the construction of scaffolds for tissue engineering has risen precipitously in recent years. The review contains materials about historic and modern applications of collagen in medicine such as soluble collagen injections, solid constructs reconstructed from solution, and decellularized collagen matrices. The analysis of published data proves the efficacy of collagen material in the treatment of chronic wounds, burns, venous and diabetic ulcers, in plastic, reconstructive and general surgery, urology, proctology, gynecology, ophthalmology, otolaryngology, neurosurgery, dentistry, cardiovascular and bone and cartilage surgery, as well as in cosmetology. Further development of collagenoplasty requires addressing the problems of allergic complications, improvement of structure and maximizing therapeutic effects against pathological processes.
Keywords: Collagen, natural polymer, reconstructed collagen, decellularized collagen matrix, scaffold, tissue engineering.
[1]
Mienaltowski, M.J.; Birk, D.E. Structure, physiology, and biochemistry of collagens. Adv. Exp. Med. Biol., 2014, 802, 5-29.
[3]
Shoulders, M.D.; Raines, R.T. Collagen structure and stability. Annu. Rev. Biochem., 2009, 78, 929-958.
[4]
Trelstad, R.L. Human aorta collagens: Evidence for three distinct species. Biochem. Biophys. Res. Commun., 1974, 57(3), 717-725.
[5]
Pappas, A.M.; Hyatt, G.W. The evaluation of collagen film applied to skin defects in mice. Surg. Forum, 1960, 10, 844-846.
[6]
McBride, C.M.; Healey, J.E., Jr; Butler, J.J.; White, E.C. Use collagen cloth for repair of tissue defects. Surg. Forum, 1964, 15, 70-71.
[7]
Abbenhaus, J.I.; Donald, P. The use of collagen grafts for replacement of major skin loss. Laryngoscope, 1971, 81(10), 1650-1651.
[8]
Wanke, M.; Collins, R.L.; Hartmann, R.; Linder, M.M.; Sebening, H. [Structure dependent wound healing with temporary skin substitute of collagen foam film] Frankf. Z. Pathol., 1967, 77(2), 125-134.
[9]
Friderich, H.G.; Vakilzadeh, F.; Goebel, M. Study of wound healing with animal collagen films. Z. Haut. U. Geschl. Kr., 1968, 5, 325-334.
[10]
Morgenstern, L. Experimental partial splenectomy: application of cyanoacrylate monomer tissue adhesive for hemostasis. Am. Surg., 1965, 31(11), 709-712.
[11]
Peacock, E.E., Jr; Seigler, H.F.; Biggers, P.W. Use of tanned col-lagen sponges in the treatment of liver injuries. Ann. Surg., 1965, 161, 238-247.
[12]
Preobrazhensky, N.; Goldman, I.I.; Aboyants, R.K.; Ruden-ko, T.G. Application of collagen in reconstruction of auris media. News Otolaryngol., 1973, 6, 57-62.
[13]
Dronov, A.F.; Rudenko, T.G.; Arutunova, V.A. Collagen-minomycin complex. Antibiotics (Basel), 1977, 3, 283-286.
[14]
Rudenko, T.G.; Dronov, A.F.; Geraskin, V.I.; Shtihno, O.F. Experimental application of collagen-minomycin sponge Clin. Aspects Surg. Anat. Exp. Surgery, 1979. 137-141
[15]
Segalova, N.E.; Dubinskaya, A.M.; Istranov, L.P.; Aboyants, R.K.; Nikitina, L.A.; Rudenko, T.G. Preparation and properties of composites of collagen with terrilitin. Pharm. Chem. J., 1988, 22(6), 491-495.
[16]
Istranov, L.P.; Aboyants, R.K.; Belozerskaya, G.G.; Istrano-va, E.V.; Makarov, V.A. Local hemostatic collagen materials. Pharmacy (Basel), 2007, 7, 29-32.
[17]
Vaza, A.U.; Shekhter, A.B.; Istranov, L.P.; Kanakov, I.V. Experimental development of method for stimulated healing of bone-cartilage defects. . Healthcare and medical technologies, 2008, 1 8-12
[18]
Ermolova, A.S.; Smirnova, S.V.; Hvatov, V.B.; Istranov, L.P.; Mironov, L.L.; Kolokolchikova, E.G.; Sichevsky, M.V.; Bocharova, V.S. Biological dressing for III degree burn wounds. Surgery, 2008, 10, 4-9.
[19]
Istranova, E.V.; Aboyants, R.K.; Istranov, L.P. Antimicrobal activity of collagen sponges. Pharmacy (Basel), 2011, 1, 34-37.
[20]
Istranova, E.V.; Istranov, L.P.; Aboyants, R.K.; Chertova, E.N. Ichtiol – new collagen substance. PharmacyI., 2004, 5, 34-37.
[22]
Levchik, E.U.; Aboyants, R.K.; Istranov, L.P.; Rudenko, T.G. External protection of the intestine anastomoses by col-lagen explants. Immunol. Lett., 1997, 56(2), 490.
[23]
Shekhter, A.B.; Rudenko, T.G.; Istranov, L.P.; Guller, A.E.; Borodulin, R.R.; Vanin, A.F. Dinitrosyl iron complexes with glutathione incorporated into a collagen matrix as a base for the design of drugs accelerating skin wound healing. Eur. J. Pharm. Sci., 2015, 78, 8-18.
[24]
Shekhter, A.B.; Guller, A.E.; Istranov, L.P.; Istranova, E.V.; Butnaru, D.V.; Vinarov, A.Z.; Zakharkina, O.L.; Kurkov, A.V.; Kantimerov, D.F.; Antonov, E.N.; Marisov, L.V.; Glybochko, P.V. [Morphology of collagen matrices for tissue engineering (biocompatibility, biodegradation, tissue response)]. Arkh. Patol., 2015, 77(6), 29-38.
[25]
Shekhter, A.B. Connective tissue as an integral system: role of cell-cell and cell-matrix interactions. Connect. Tissue Res., 1986, 15(1-2), 23-31.
[26]
Lucey, P.; Goldberg, D.J. Complications of collagen fillers. Facial Plast. Surg., 2014, 30(6), 615-622.
[27]
Parenteau-Bareil, R.; Gauvin, R.; Berthod, F. Collagen-based biomaterials for tissue engineering applications. Materials (Basel), 2010, 3(3), 1863-1887.
[28]
Motta, G.; Ratto, G.B.; De Barbieri, A.; Corte, G.; Zardi, L.; Sacco, A.; Castagnola, M. Can heterologous collagen enhance the granulation tissue growth? An experimental study. Ital. J. Surg. Sci., 1983, 13(2), 101-108.
[29]
Singh, O.; Gupta, S.S.; Soni, M.; Moses, S.; Shukla, S.; Mathur, R.K. Collagen dressing versus conventional dressings in burn and chronic wounds: a retrospective study. J. Cutan. Aesthet. Surg., 2011, 4(1), 12-16.
[30]
Veves, A.; Sheehan, P.; Pham, H.T.A. A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers. Arch. Surg., 2002, 137(7), 822-827.
[31]
Lou, R.B.; Hickerson, W.L. The use of skin substitutes in hand burns. Hand Clin., 2009, 25(4), 497-509.
[32]
Landsman, A.; Taft, D.; Riemer, K. The role of collagen bioscaffolds, foamed collagen, and living skin equivalents in wound healing. Clin. Podiatr. Med. Surg., 2009, 26(4), 525-533.
[33]
Landsman, A.S.; Cook, J.; Cook, E.; Landsman, A.R.; Garrett, P.; Yoon, J.; Kirkwood, A.; Desman, E. A retrospective clinical study of 188 consecutive patients to examine the effectiveness of a biologically active cryopreserved human skin allograft (Theraskin®) on the treatment of diabetic foot ulcers and venous leg ulcers. Foot Ankle Spec., 2011, 4(1), 29-41.
[34]
Ermolov, A.S.; Smirnov, S.V.; Khvatov, V.B.; Istranov, L.P.; Koniushko, O.I.; Kolokolchikova, E.G.; Sychevsky, M.V.; Bocharova, V.S. The use of bioactive wound dressing, stimulating epithelial regeneration of IIIa-degree burn wounds. Bull. Exp. Biol. Med., 2008, 146(1), 153-157.
[35]
Corcos, J.; Collet, J.P.; Shapiro, S.; Herschorn, S.; Radomski, S.B.; Schick, E.; Gajewski, J.B.; Benedetti, A.; MacRamallah, E.; Hyams, B. Multicenter randomized clinical trial comparing surgery and collagen injections for treatment of female stress urinary incontinence. Urology, 2005, 65(5), 898-904.
[36]
Davis, N.F.; Kheradmand, F.; Creagh, T. Injectable biomaterials for the treatment of stress urinary incontinence: Their potential and pitfalls as urethral bulking agents. Int. Urogynecol. J. Pelvic Floor Dysfunct., 2013, 24(6), 913-919.
[37]
Läckgren, G.; Wåhlin, N.; Stenberg, A. Endoscopic treatment of children with vesico-ureteric reflux. Acta Paediatr. Suppl., 1999, 88(431), 62-71.
[38]
Maeda, Y.; Laurberg, S.; Norton, C.S. Perianal injectable bulking agents as treatment for faecal incontinence. Cochrane Database Syst. Rev., 2009, 15(3), CD007956.
[39]
King, J.M.; Simpson, C.B. Modern injection augmentation for glottic insufficiency. Curr. Opin. Otolaryngol. Head Neck Surg., 2007, 15(3), 153-158.
[40]
Kościński, T.; Szubert, S.; Sajdak, S. Advantages of implantation of acellular porcine-derived mesh in the treatment of human rectocele - Case report. Ann. Agric. Environ. Med., 2016, 23(4), 692-695.
[41]
Slater, N.J.; van der Kolk, M.; Hendriks, T.; van Goor, H.; Bleichrodt, R.P. Biologic grafts for ventral hernia repair: A systematic review. Am. J. Surg., 2013, 205(2), 220-230.
[42]
Kissane, N.A.; Itani, K.M.F. A decade of ventral incisional hernia repairs with biologic acellular dermal matrix. Plast. Reconstr. Surg., 2012, 130(5)(Suppl. 2), 194S-202S.
[43]
Ibrahim, A.M.S.; Ayeni, O.A.; Hughes, K.B.; Lee, B.T.; Slavin, S.A.; Lin, S.J. Acellular dermal matrices in breast surgery: A comprehensive review. Ann. Plast. Surg., 2013, 70(6), 732-738.
[45]
Akbal, C.; Lee, S.D.; Packer, S.C.; Davis, M.M.; Rink, R.C.; Kaefer, M. Bladder augmentation with acellular dermal biomatrix in a diseased animal model. J. Urol., 2006, 176(4 Pt 2)(Suppl.), 1706-1711.
[46]
Lin, J.; Hao, J.R.; Jin, J.; Deng, S.M.; Hu, J.; Na, Y.Q. [Homologous dermal acellular matrix graft for urethral reconstruction in man (report of 16 cases)]. Zhonghua Yi Xue Za Zhi, 2005, 85(15), 1057-1059.
[47]
Atala, A.; Bauer, S.B.; Soker, S.; Yoo, J.J.; Retik, A.B. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet, 2006, 367(9518), 1241-1246.
[48]
Raya-Rivera, A.M.; Esquiliano, D.; Fierro-Pastrana, R.; López-Bayghen, E.; Valencia, P.; Ordorica-Flores, R.; Soker, S.; Yoo, J.J.; Atala, A. Tissue-engineered autologous vaginal organs in patients: A pilot cohort study. Lancet, 2014, 384(9940), 329-336.
[49]
Hamilton, N.J.; Kanani, M.; Roebuck, D.J.; Hewitt, R.J.; Cetto, R.; Culme-Seymour, E.J.; Toll, E.; Bates, A.J.; Comerford, A.P.; McLaren, C.A.; Butler, C.R.; Crowley, C.; McIntyre, D.; Sebire, N.J.; Janes, S.M.; O’Callaghan, C.; Mason, C.; De Coppi, P.; Lowdell, M.W.; Elliott, M.J.; Birchall, M.A. Tissue-engineered tracheal replacement in a child: A 4-year follow-up study. Am. J. Transplant., 2015, 15(10), 2750-2757.
[50]
Erdogan, D.; van Gulik, T.M. Evolution of fibrinogen-coated collagen patch for use as a topical hemostatic agent. J. Biomed. Mater. Res. B Appl. Biomater., 2008, 85(1), 272-278.
[51]
Fleischer, D. Endoscopic therapy of upper gastrointestinal bleeding in humans. Gastroenterology, 1986, 90(1), 217-234.
[52]
Chang, W.K.; Srinivasa, S.; MacCormick, A.D.; Hill, A.G. Gentamicin-collagen implants to reduce surgical site infection. Ann. Surg., 2013, 258(1), 59-65.
[53]
Creanor, S.; Barton, A.; Marchbank, A. Effectiveness of a gentamicin impregnated collagen sponge on reducing sternal wound infections following cardiac surgery: a meta-analysis of randomised controlled trials. Ann. R. Coll. Surg. Engl., 2012, 94(4), 227-231.
[54]
Hussain, S.T. Local application of gentamicin-containing collagen implant in the prophylaxis and treatment of surgical site infection following vascular surgery. Int. J. Surg., 2012, 10(Suppl. 1), S5-S9.
[55]
de Bruin, A.F.J.; Gosselink, M.P.; van der Harst, E. Local application of gentamicin-containing collagen implant in the prophylaxis of surgical site infection following gastrointestinal surgery. Int. J. Surg., 2012, 10(Suppl. 1), S21-S27.
[56]
Knaepler, H. Local application of gentamicin-containing collagen implant in the prophylaxis and treatment of surgical site infection in orthopaedic surgery. Int. J. Surg., 2012, 10(Suppl. 1), S15-S20.
[57]
Grigoryants, V.; Jane, J.A., Jr; Lin, K.Y. Salvage of a complicated myelomeningocele using collagen (Duragen) and dermal (Alloderm) matrix substitutes. Case report and review of the literature. Pediatr. Neurosurg., 2007, 43(6), 512-515.
[58]
Deal, D.N.; Griffin, J.W.; Hogan, M.V. Nerve conduits for nerve repair or reconstruction. J. Am. Acad. Orthop. Surg., 2012, 20(2), 63-68.
[59]
Khaing, Z.Z.; Schmidt, C.E. Advances in natural biomaterials for nerve tissue repair. Neurosci. Lett., 2012, 519(2), 103-114.
[60]
Pabari, A.; Yang, S.Y.; Mosahebi, A.; Seifalian, A.M. Recent advances in artificial nerve conduit design: Strategies for the delivery of luminal fillers. J. Control. Release, 2011, 156(1), 2-10.
[61]
Han, S.; Wang, B.; Jin, W.; Xiao, Z.; Li, X.; Ding, W.; Kapur, M.; Chen, B.; Yuan, B.; Zhu, T.; Wang, H.; Wang, J.; Dong, Q.; Liang, W.; Dai, J. The linear-ordered collagen scaffold-BDNF complex significantly promotes functional recovery after completely transected spinal cord injury in canine. Biomaterials, 2015, 41, 89-96.
[62]
Fagerholm, P.; Lagali, N.S.; Ong, J.A.; Merrett, K.; Jackson, W.B.; Polarek, J.W.; Suuronen, E.J.; Liu, Y.; Brunette, I.; Griffith, M. Stable corneal regeneration four years after implantation of a cell-free recombinant human collagen scaffold. Biomaterials, 2014, 35(8), 2420-2427.
[63]
Sultana, Y.; Jain, R.; Aqil, M.; Ali, A. Review of ocular drug delivery. Curr. Drug Deliv., 2006, 3(2), 207-217.
[64]
Cillino, S.; Di Pace, F.; Cillino, G.; Casuccio, A. Biodegradable collagen matrix implant vs mitomycin-C as an adjuvant in trabeculectomy: A 24-month, randomized clinical trial. Eye (Lond.), 2011, 25(12), 1598-1606.
[65]
Hayek, B.; Hatef, E.; Nguyen, M.; Ho, V.; Hsu, A.; Esmaeli, B. Acellular dermal graft (AlloDerm) for upper eyelid reconstruction after cancer removal. Ophthal. Plast. Reconstr. Surg., 2009, 25(6), 426-429.
[66]
Peter, N.M.; Kumar, B. Permacol in eyelid reconstruction -- a novel use. Orbit, 2013, 32(1), 57-59.
[67]
Haynes, D.S.; Vos, J.D.; Labadie, R.F. Acellular allograft dermal matrix for tympanoplasty. Curr. Opin. Otolaryngol. Head Neck Surg., 2005, 13(5), 283-286.
[68]
Gryskiewicz, J.M. Waste not, want not: The use of AlloDerm in secondary rhinoplasty. Plast. Reconstr. Surg., 2005, 116(7), 1999-2004.
[69]
Gillogly, S.D.; Wheeler, K.S. Autologous chondrocyte implantation with collagen membrane. Sports Med. Arthrosc. Rev., 2015, 23(3), 118-124.
[70]
Grassi, A.; Zaffagnini, S.; Marcheggiani Muccioli, G.M.; Benzi, A.; Marcacci, M. Clinical outcomes and complications of a collagen meniscus implant: A systematic review. Int. Orthop., 2014, 38(9), 1945-1953.
[71]
Zaffagnini, S.; Grassi, A.; Marcheggiani Muccioli, G.M.; Bonanzinga, T.; Nitri, M.; Raggi, F.; Ravazzolo, G.; Marcacci, M. MRI evaluation of a collagen meniscus implant: A systematic review. Knee Surg. Sports Traumatol. Arthrosc., 2015, 23(11), 3228-3237.
[72]
Ferreira, A.M.; Gentile, P.; Chiono, V.; Ciardelli, G. Collagen for bone tissue regeneration. Acta Biomater., 2012, 8(9), 3191-3200.
[73]
Huang, Z.; Feng, Q.; Yu, B.; Li, S. Biomimetic properties of an injectable chitosan/nano-hydroxyapatite/ collagen composite. Mater. Sci. Eng. C, 2011, 31(3), 683-687.
[74]
Sotome, S.; Uemura, T.; Kikuchi, M.; Chen, J.; Itoh, S.; Tanaka, J.; Tateishi, T.; Shinomiya, K. Synthesis and in vivo evaluation of a novel hydroxyapatite/collagen–alginate as a bone filler and a drug delivery carrier of bone morphogenetic protein. Mater. Sci. Eng. C, 2004, 24(3), 341-347.
[75]
Van Vijven, J.P.J.; Luijsterburg, P.A.J.; Verhagen, A.P.; van Osch, G.J.V.M.; Kloppenburg, M.; Bierma-Zeinstra, S.M.A. Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: A systematic review. Osteoarthritis Cartilage, 2012, 20(8), 809-821.
[76]
Park, K.S.; Park, M.J.; Cho, M.L.; Kwok, S.K.; Ju, J.H.; Ko, H.J.; Park, S.H.; Kim, H.Y.; Type, I.I. Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis. Mod. Rheumatol., 2009, 19(6), 581-589.
[77]
Thoma, D.S.; Buranawat, B.; Hämmerle, C.H.F.; Held, U.; Jung, R.E. Efficacy of soft tissue augmentation around dental implants and in partially edentulous areas: a systematic review. J. Clin. Periodontol., 2014, 41(Suppl. 15), S77-S91.
[78]
Patino, M.G.; Neiders, M.E.; Andreana, S.; Noble, B.; Cohen, R.E. Collagen as an implantable material in medicine and dentistry. J. Oral Implantol., 2002, 28(5), 220-225.
[79]
Huang, A.H.; Niklason, L.E. Engineering of arteries in vitro. Cell. Mol. Life Sci., 2014, 71(11), 2103-2118.
[80]
Keuren, J.F.W.; Wielders, S.J.H.; Driessen, A.; Verhoeven, M.; Hendriks, M.; Lindhout, T. Covalently-bound heparin makes collagen thromboresistant. Arterioscler. Thromb. Vasc. Biol., 2004, 24(3), 613-617.
[81]
Sanz-Garcia, A.; Oliver-de-la-Cruz, J.; Mirabet, V.; Gandía, C.; Villagrasa, A.; Sodupe, E.; Escobedo-Lucea, C. Heart valve tissue engineering: How far is the bedside from the bench? Expert Rev. Mol. Med., 2015, 17, e16.
[82]
Hilkin, A.M.; Shekhter, A.B.; Istranov, L.P.; Lemenev, V.L. Collagen and its application in medicine., 1976.
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