金属与帕金森病：机制与生化过程

Title:Metals and Parkinson's Disease: Mechanisms and Biochemical Processes

Volume: 25 Issue: 19

关键词: 黑质，α-突触素，β-淀粉样蛋白，谷氨酸，谷胱甘肽，氧化应激，金属，多巴胺

摘要: Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease (PD), while the remaining cases are of unknown etiology. It is believed that environmental factors may be involved in the causality of a large proportion of PD cases. Several PD genes are activated by xenobiotic exposure, and a link between pesticide exposure and PD has been demonstrated. Many epidemiological studies have shown an association between PD and exposure to metals such as mercury, lead, manganese, copper, iron, aluminum, bismuth, thallium, and zinc. This review explores the biological effects, the pathogenetic processes, genetic susceptibilities to metals as well as examining future strategies for PD treatment, such as chelation therapy.

Cite this article as:

Metals and Parkinson's Disease: Mechanisms and Biochemical Processes, Current Medicinal Chemistry 2018; 25 (19) . https://dx.doi.org/10.2174/0929867325666171129124616