Metals and Parkinson's Disease: Mechanisms and Biochemical Processes

Title:Metals and Parkinson's Disease: Mechanisms and Biochemical Processes

Volume: 25 Issue: 19

Author(s): Geir Bjorklund*, Vera Stejskal, Mauricio A. Urbina, Maryam Dadar, Salvatore Chirumbolo and Joachim Mutter

Affiliation:

• Council for Nutritional and Environmental Medicine, Mo i Rana,Norway

Keywords: Substantia nigra, alpha-synuclein, beta-amyloid, glutamate, glutathione, oxidative stress, metals, dopamine.

Abstract: Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease (PD), while the remaining cases are of unknown etiology. It is believed that environmental factors may be involved in the causality of a large proportion of PD cases. Several PD genes are activated by xenobiotic exposure, and a link between pesticide exposure and PD has been demonstrated. Many epidemiological studies have shown an association between PD and exposure to metals such as mercury, lead, manganese, copper, iron, aluminum, bismuth, thallium, and zinc. This review explores the biological effects, the pathogenetic processes, genetic susceptibilities to metals as well as examining future strategies for PD treatment, such as chelation therapy.

Cite this article as:

Bjorklund Geir*, Stejskal Vera , Urbina A. Mauricio, Dadar Maryam, Chirumbolo Salvatore and Mutter Joachim , Metals and Parkinson's Disease: Mechanisms and Biochemical Processes, Current Medicinal Chemistry 2018; 25 (19) . https://dx.doi.org/10.2174/0929867325666171129124616