Abstract
Background: Identifying dysregulated pathways from significant differential expression genes (DEGs) to infer underlying biological insights play an important role in discovering pathogenesis of diseases. However, current pathway-based methods only focus on single pathways in isolation and the analysis of the pathways crosstalk that contains DEGs could improve our understanding of alterations in biological processes.
Objective: To explore the underlying dysregulated pathways of Alzheimer's disease (AD) efficiently by the crosstalk analysis on both the significant DEGs and the pathways with high contributions.
Method: A novel signaling pathway impact analysis method is used to calculate and rank the signaling pathways of AD. Distance correlation model based on the pathways with ranking contributions is applied to calculate the crosstalk of pathways of AD.
Results: The method not only confirms the presence of known pathways associated with AD including Parkinson's disease, Vegf signaling pathway and so on but also predicts the presence of unknown pathways such as Basal cell carcinoma and Olfactory transduction pathways that are significantly associated with the onset and deterioration of AD.
Conclusion: The results provide useful supplement and basis for the biological experiments of AD pathogenesis.
Keywords: DEGs, pathway-based, crosstalk, distance correlation, Alzheimer's disease, ranking contributions.
Graphical Abstract
Current Proteomics
Title:Pathway Crosstalk Analysis based on Signaling Pathway Impact Analysis in Alzheimer's Disease
Volume: 15 Issue: 2
Author(s): Jin Deng, Wei Kong*, Xiaoyang Mou and Shuaiqun Wang
Affiliation:
- College of Information Engineering, Shanghai Maritime University, 1550 Haigang Ave., Shanghai 201306,China
Keywords: DEGs, pathway-based, crosstalk, distance correlation, Alzheimer's disease, ranking contributions.
Abstract: Background: Identifying dysregulated pathways from significant differential expression genes (DEGs) to infer underlying biological insights play an important role in discovering pathogenesis of diseases. However, current pathway-based methods only focus on single pathways in isolation and the analysis of the pathways crosstalk that contains DEGs could improve our understanding of alterations in biological processes.
Objective: To explore the underlying dysregulated pathways of Alzheimer's disease (AD) efficiently by the crosstalk analysis on both the significant DEGs and the pathways with high contributions.
Method: A novel signaling pathway impact analysis method is used to calculate and rank the signaling pathways of AD. Distance correlation model based on the pathways with ranking contributions is applied to calculate the crosstalk of pathways of AD.
Results: The method not only confirms the presence of known pathways associated with AD including Parkinson's disease, Vegf signaling pathway and so on but also predicts the presence of unknown pathways such as Basal cell carcinoma and Olfactory transduction pathways that are significantly associated with the onset and deterioration of AD.
Conclusion: The results provide useful supplement and basis for the biological experiments of AD pathogenesis.
Export Options
About this article
Cite this article as:
Deng Jin , Kong Wei *, Mou Xiaoyang and Wang Shuaiqun , Pathway Crosstalk Analysis based on Signaling Pathway Impact Analysis in Alzheimer's Disease, Current Proteomics 2018; 15 (2) . https://dx.doi.org/10.2174/1570164614666171030162949
DOI https://dx.doi.org/10.2174/1570164614666171030162949 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
CD36-TSP-HRGP Interactions in the Regulation of Angiogenesis
Current Pharmaceutical Design Omega-3 Polyunsaturated Fatty Acids and Cancer
Anti-Cancer Agents in Medicinal Chemistry Dissecting Insulin Signaling Pathways: Individualised Therapeutic Targets for Diagnosis and Treatment of Insulin Resistant States
Endocrine, Metabolic & Immune Disorders - Drug Targets Plant Derived Inhibitor Sulforaphane in Combinatorial Therapy Against Therapeutically Challenging Pancreatic Cancer
Anti-Cancer Agents in Medicinal Chemistry Purines and Pyrimidines: Metabolism, Function and Potential as Therapeutic Options in Neurodegenerative Diseases
Current Protein & Peptide Science Emerging Therapies in Chronic Myeloid Leukemia
Current Cancer Drug Targets Cell Metabolism Under Microenvironmental Low Oxygen Tension Levels in Stemness, Proliferation and Pluripotency
Current Molecular Medicine Advances in Mitotic Inhibitors for Cancer Treatment
Mini-Reviews in Medicinal Chemistry The Effect of Chemotherapy/Radiotherapy on Cancerous Pattern Recognition by NK Cells
Current Medicinal Chemistry Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids
Current Topics in Medicinal Chemistry Recent Developments in Targeting Breast Cancer Stem Cells
Recent Patents on Regenerative Medicine Tumor Invasion and Oxidative Stress: Biomarkers and Therapeutic Strategies
Current Molecular Medicine Natural and Synthetic Agents Targeting Inflammation and Angiogenesis for Chemoprevention of Prostate Cancer
Current Cancer Drug Targets Molecular Subgrouping of Medulloblastoma: Impact Upon Research and Clinical Practice
Current Pediatric Reviews Radiolabeled Glucose Derivatives for Tumor Imaging Using SPECT and PET
Current Medicinal Chemistry Receptor Tyrosine Kinases Take a Direct Route to Mitochondria: An Overview
Current Protein & Peptide Science Bone Morphogenetic Protein-Smad Pathway as Drug Targets for Osteoporosis and Cancer Therapy
Endocrine, Metabolic & Immune Disorders - Drug Targets EBI2, GPR18, and GPR17 – Three Structurally Related but Biologically Distinct 7TM Receptors
Current Topics in Medicinal Chemistry Innovative formulations for controlled drug delivery to the lungs and the technical and toxicological challenges to overcome<sup>#</sup>
Current Pharmaceutical Design Evolution of Exenatide as a Diabetes Therapeutic
Current Diabetes Reviews